Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination

Measurement of glomerular filtration rate (GFR) in children by iohexol injection and blood sampling from the contralateral arm is widely used. A single intravenous access for iohexol injection and subsequent blood sampling has the obvious advantages of being less painful and easier to perform. The p...

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Bibliographic Details
Published in:Scientific reports 2021-12, Vol.11 (1), p.23224-23224, Article 23224
Main Authors: Eide, Thea Tislevoll, Hufthammer, Karl Ove, Brun, Atle, Brackman, Damien, Svarstad, Einar, Tøndel, Camilla
Format: Article
Language:English
Subjects:
692/308
692/4022
Administration, Intravenous
Adolescent
Blood
Blood Specimen Collection - methods
Child
Children
Contamination
Dogs
Flushing
Glomerular Filtration Rate
Humanities and Social Sciences
Humans
Injection
Intravenous administration
Iohexol - administration & dosage
Iohexol - pharmacokinetics
Kidney diseases
Metabolic Clearance Rate
multidisciplinary
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Sampling
Science
Science (multidisciplinary)
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Summary:Measurement of glomerular filtration rate (GFR) in children by iohexol injection and blood sampling from the contralateral arm is widely used. A single intravenous access for iohexol injection and subsequent blood sampling has the obvious advantages of being less painful and easier to perform. The purpose of our study was to determine if blood samples drawn from the injection access are feasible and accurate for iohexol GFR (iGFR) measurements. Thirty-one children, median age 10.5 (range 6–17) years, with chronic kidney disease were given a bolus of iohexol followed by extended saline flushing and subsequent venous blood samples collected from the injection access as well as from a cannula in the contralateral arm, the latter serving as the reference method. Paired venous blood samples were collected at four time points (2, 3, 3.5 and 4 h) after the iohexol bolus. Blood sample discarding preceded and saline flushing followed each blood sampling to avoid marker contamination. iGFR based on samples drawn from the injection access at 2 and 3 h showed significantly lower iGFR than measurement from the contralateral arm (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-02759-1