An overview on autologous fibrin glue in bone tissue engineering of maxillofacial surgery

The purpose of this review is to have an overview on the applications on the autologous fibrin glue as a bone graft substitute in maxillofacial injuries and defects. A search was conducted using the databases such as Medline or PubMed and Google Scholar for articles from 1985 to 2016. The criteria w...

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Bibliographic Details
Published in:Dental research journal 2017-03, Vol.14 (2), p.79-86
Main Authors: Khodakaram-Tafti, Azizollah, Mehrabani, Davood, Shaterzadeh-Yazdi, Hanieh
Format: Article
Language:English
Subjects:
Adhesives
Antifibrinolytic agents
Autograft
Biocompatibility
Biomedical materials
Blood platelets
Bone surgery
Bones
Defects
Dental implants
fibrin tissue adhesive
Growth factors
maxillofacial injury
Maxillofacial surgery
Polymers
Proteins
Review
Stem cells
Tissue engineering
Transplants & implants
Veterinary colleges
Veterinary medicine
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Summary:The purpose of this review is to have an overview on the applications on the autologous fibrin glue as a bone graft substitute in maxillofacial injuries and defects. A search was conducted using the databases such as Medline or PubMed and Google Scholar for articles from 1985 to 2016. The criteria were "Autograft," "Fibrin tissue adhesive," "Tissue engineering," "Maxillofacial injury," and "Regenerative medicine." Bone tissue engineering is a new promising approach for bone defect reconstruction. In this technique, cells are combined with three-dimensional scaffolds to provide a tissue-like structure to replace lost parts of the tissue. Fibrin as a natural scaffold, because of its biocompatibility and biodegradability, and the initial stability of the grafted stem cells is introduced as an excellent scaffold for tissue engineering. It promotes cell migration, proliferation, and matrix making through acceleration in angiogenesis. Growth factors in fibrin glue can stimulate and promote tissue repair. Autologous fibrin scaffolds are excellent candidates for tissue engineering so that they can be produced faster, cheaper, and in larger quantities. In addition, they are easy to use and the probability of viral or prion transmission may be decreased. Therefore, autologous fibrin glue appears to be promising scaffold in regenerative maxillofacial surgery.
ISSN:1735-3327
2008-0255
DOI:10.4103/1735-3327.205789