Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia

Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may...

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Published in:Clinical case reports 2021-05, Vol.9 (5), p.e04115-n/a
Main Authors: Ott, Ashley, Venkataraman, Vinayak, Badran, Yousef R., Goldman, Rose, Spasic, Smiljana, Vyas, Darshali A., Amrein, Philip, McAfee, Steven, Brunner, Andrew, Fathi, Amir T., Narayan, Rupa
Format: Article
Language:English
Subjects:
Abdomen
Antibiotics
APL
APML
Arsenic
Blood
Cardiac arrhythmia
Case Report
Case Reports
Creatinine
Diarrhea
Drug dosages
Induction therapy
Leukemia
Metabolites
Nausea
obesity
Pancreatitis
Patients
Peripheral neuropathy
Poisoning
renal insufficiency
Severe acute respiratory syndrome coronavirus 2
Toxicity
Urine
Vomiting
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cited_by cdi_FETCH-LOGICAL-c5715-86c68147aeb1cb32705887215b525e8378d26234608bf4851c3c4e231580f1953
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creator Ott, Ashley
Venkataraman, Vinayak
Badran, Yousef R.
Goldman, Rose
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McAfee, Steven
Brunner, Andrew
Fathi, Amir T.
Narayan, Rupa
description Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may help guide dose modifications. Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may help guide dose modifications.
doi_str_mv 10.1002/ccr3.4115
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subjects Abdomen
Antibiotics
APL
APML
Arsenic
Blood
Cardiac arrhythmia
Case Report
Case Reports
Creatinine
Diarrhea
Drug dosages
Induction therapy
Leukemia
Metabolites
Nausea
obesity
Pancreatitis
Patients
Peripheral neuropathy
Poisoning
renal insufficiency
Severe acute respiratory syndrome coronavirus 2
Toxicity
Urine
Vomiting
title Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
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