Breast cancer risk and serum levels of per- and poly-fluoroalkyl substances: a case-control study nested in the California Teachers Study

Per- and poly- fluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Their potential as breast carcinogens is unclear. Our objective was to evaluate the risk of breast cancer associated with serum PFAS concentrations i...

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Bibliographic Details
Published in:Environmental health 2018-11, Vol.17 (1), p.83-83, Article 83
Main Authors: Hurley, Susan, Goldberg, Debbie, Wang, Miaomiao, Park, June-Soo, Petreas, Myrto, Bernstein, Leslie, Anton-Culver, Hoda, Nelson, David O, Reynolds, Peggy
Format: Article
Language:English
Subjects:
Acetic acid
Alkyl groups
Breast cancer
Breast cancer risk
Cancer
Carcinogens
Case control
Case studies
Diagnosis
Endocrine disruptors
Environmental health
Estrogens
Health aspects
Health risk assessment
Health risks
High-performance liquid chromatography
Hormone replacement therapy
Invasiveness
Liquid chromatography
Organic chemistry
Perfluoro compounds
Perfluoroalkyl substances
Perfluorocarbons
Perfluorohexane
Perfluorooctane sulfonic acid
Perfluorooctanoic acid
PFAS
Physiological aspects
Polyfluoroalkyl substances
Regression analysis
Risk
Risk factors
Serum levels
Statistical analysis
Statistical methods
Statistical significance
Studies
Sulfonic acid
Teachers
Teaching methods
Toxicants
Tumors
Womens health
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Summary:Per- and poly- fluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Their potential as breast carcinogens is unclear. Our objective was to evaluate the risk of breast cancer associated with serum PFAS concentrations in a nested case-control study within the California Teachers Study. Participants were 902 women with invasive breast cancer (cases) and 858 with no such diagnosis (controls) who provided 10 mL of blood and were interviewed during 2011-2015, an average of 35 months after case diagnosis. PFASs were measured using automated online SPE-HPLC-MS/MS methods. Statistical analyses were restricted to six PFASs with detection frequencies ≥ 95%: PFOA (Perfluorooctanoic acid), PFNA (Perfluorononanoic acid), PFUnDA (Perfluoroundecanoic acid), PFHxS (Perfluorohexane sulfonic acid), PFOS (Perfluorooctane sulfonic acid), and MeFOSAA (2-(N-Methyl-perfluorooctane sulfonamido) acetic acid. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs), estimating the breast cancer risk associated with each PFAS. For all cases of invasive breast cancer, none of the adjusted ORs were statistically significant but marginally significant ORs 
ISSN:1476-069X
1476-069X
DOI:10.1186/s12940-018-0426-6