Lemairamin (Wgx-50) Attenuates DSS-Induced Intestinal Inflammation in Zebrafish

Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease that affects millions of people worldwide, and current treatment methods have certain limitations. This study aimed to explore the therapeutic potential and mechanism of action of lemairamin (Wgx-50) in inflam...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-09, Vol.25 (17), p.9510
Main Authors: Zhang, Ling, Liu, Huiru, Zhang, Haoyi, Yuan, Hao, Ren, Dalong
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Colitis - chemically induced
Colitis - drug therapy
Colitis - metabolism
Colitis - pathology
Cytokines
Cytokines - metabolism
Dextran Sulfate - adverse effects
Disease Models, Animal
DSS
IBD
Inflammation
Inflammation - chemically induced
Inflammation - drug therapy
Inflammation - metabolism
Inflammation - pathology
Inflammatory bowel disease
Inflammatory Bowel Diseases - chemically induced
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - metabolism
Inflammatory Bowel Diseases - pathology
Intestines - drug effects
Intestines - pathology
Morphology
Neutrophils
Neutrophils - drug effects
Neutrophils - metabolism
Physiology
Proto-Oncogene Proteins c-akt - metabolism
Recruitment
Signal Transduction - drug effects
Wgx-50
Zebrafish
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Summary:Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease that affects millions of people worldwide, and current treatment methods have certain limitations. This study aimed to explore the therapeutic potential and mechanism of action of lemairamin (Wgx-50) in inflammatory bowel disease (IBD). We used dextran sulfate sodium (DSS)-treated zebrafish as an inflammatory bowel disease model, and observed the effect of Wgx-50 on DSS-induced colitis inflammation. The results of the study showed that Wgx-50 could reduce the expression of pro-inflammatory cytokines induced by DSS and inhibit the recruitment of neutrophils to the site of intestinal injury. Further experiments revealed that Wgx-50 exerted its anti-inflammatory effect by regulating the activation of the Akt pathway. These research findings indicate that Wgx-50 possesses anti-inflammatory activity.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25179510