The Characteristics Of Abdominal Fat Distribution In Japanese Adolescents With Type 2 Diabetes Mellitus

• Published in: Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2019-11, Vol.12, p.2281-2288
• Main Authors: Abe, Yuriko, Urakami, Tatsuhiko, Hara, Mitsuhiko, Yoshida, Kei, Mine, Yusuke, Aoki, Masako, Suzuki, Junichi, Saito, Emiko, Yoshino, Yayoi, Iwata, Fujihiko, Okada, Tomoo, Morioka, Ichiro
• Format: Article
• Language: English
• Subjects: Adolescent obesity; Analysis; computed tomography; Diabetes mellitus; hemoglobin a1c; Original Research; Regression analysis; simple obesity; subcutaneous fat; Type 2 diabetes; visceral fat; Youth
• ISSN: 1178-7007; 1178-7007
• DOI: 10.2147/DMSO.S223049

The aim was to investigate the characteristics of abdominal fat distribution in Japanese adolescents with type 2 diabetes mellitus. Eighty-six Japanese adolescents with simple obesity or type 2 diabetes mellitus treated between 2002 and 2018 were included. The subjects were classified into the simple obesity group (SO group, n=38) and type 2 diabetes mellitus group (DM group, n=23) by matching average age and gender ratio. The metabolic parameters VFA, SFA, and V/S ratio were compared between the 2 groups. Multivariate logistic regression analysis was performed to identify clinical factors associated with type 2 diabetes mellitus. Linear regression analysis was performed between hemoglobin A1c (HbA1c) and visceral fat area (VFA), subcutaneous fat area (SFA), or VFA-to-SFA ratio (V/S ratio) among all enrolled subjects. Finally, correlation analyses were performed to determine the relationships between VFA, SFA, and V/S ratio and metabolic parameters of the DM group. For the metabolic parameters, serum lipids, alanine aminotransferase (ALT), and HbA1c were measured without fasting. The VFA and SFA at umbilical level were investigated using computed tomography. VFA and V/S ratio in DM group were higher than those in SO group (p=0.04 and p