Effect of Caryocar coriaceum Wittm. fixed oil on body weight and metabolic parameters of mice fed a high-fat diet

• Published in: Food chemistry advances 2024-12, Vol.5, p.100855, Article 100855
• Main Authors: da Silva, Aline Almeida, Borges, Otília Monica Alves, de Alencar, Nylane Maria Nunes, Vasconcelos, Renata Prado, de Oliveira, Ariclécio Cunha, Gaban, Socorro Vanesca Frota
• Format: Article
• Language: English
• Subjects: Edible fixed oil; Fatty acids; Obesity; Oleic acidy; Traditional medicine
• ISSN: 2772-753X; 2772-753X
• DOI: 10.1016/j.focha.2024.100855

•Pequi (Caryocar coryaceum) fixed oil had no effect on body weight in mice.•Pequi fixed oil had no effect on food intake and glucose response in mice.•The fat depots were not affected by pequi fixed oil in mice.•Pequi fixed oil was ineffective in treating obesity in mice. This study examined the effects of C. coriaceum-fixed oil in mice fed a high-fat diet (HFD). The animals were divided into three groups: those receiving a standard diet (SD), those on an HFD, and those on a high-fat diet supplemented with pequi-fixed oil (HFDPO). The animals were maintained on their respective diets for a duration of 27 weeks, during which the pequi fixed oil (100 mg/kg/day) was administered orally via gavage once daily for the final 9 weeks of the study. A glucose tolerance test was performed 1 day before animal sacrifice, and adipose tissue samples were collected. Although all groups initially had similar food intakes, the HFD and HFDPO groups showed reduced food intake compared with the standard diet group. Both groups also had increased body weights and higher fat weights than the SD group. Additionally, the HFD and HFDPO groups had higher glucose levels and significantly higher area under the curves (AUCs) than the SD group. There were no significant differences in the glucose tolerance test (GTT) and AUC between the HFD and HFDPO groups. In this study, pequi-fixed oil was ineffective in treating obesity induced by a high-fat diet. [Display omitted]