Flaviviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

The innate immune system is the host's first line of defense against the invasion of pathogens including flavivirus. The programmed cell death controlled by genes plays an irreplaceable role in resisting pathogen invasion and preventing pathogen infection. However, the inflammatory cell death,...

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Bibliographic Details
Published in:Frontiers in immunology 2022-01, Vol.13, p.829433-829433
Main Authors: Pan, Yuhong, Cai, Wenjun, Cheng, Anchun, Wang, Mingshu, Yin, Zhongqiong, Jia, Renyong
Format: Article
Language:English
Subjects:
Animals
Cell Death
cytokines
Cytokines - metabolism
Flavivirus - classification
Flavivirus - immunology
Flavivirus - physiology
flaviviruses
Host-Pathogen Interactions
Humans
Immunity, Innate
Immunology
inflammasome
Inflammasomes - metabolism
inflammatory cell death
innate immune
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Summary:The innate immune system is the host's first line of defense against the invasion of pathogens including flavivirus. The programmed cell death controlled by genes plays an irreplaceable role in resisting pathogen invasion and preventing pathogen infection. However, the inflammatory cell death, which can trigger the overflow of a large number of pro-inflammatory cytokines and cell contents, will initiate a severe inflammatory response. In this review, we summarized the current understanding of the innate immune response, inflammatory cell death pathway and cytokine secretion regulation during Dengue virus, West Nile virus, Zika virus, Japanese encephalitis virus and other flavivirus infections. We also discussed the impact of these flavivirus and viral proteins on these biological processes. This not only provides a scientific basis for elucidating the pathogenesis of flavivirus, but also lays the foundation for the development of effective antiviral therapies.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.829433