Birth weight, family history of diabetes and diabetes onset in schizophrenia

IntroductionThe prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation.ObjectiveTo test if abnormal birth weight (either too low or too high) and parental diabetes, both variables...

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Bibliographic Details
Published in:BMJ open diabetes research & care 2020-01, Vol.8 (1), p.e001036
Main Authors: Fernandez-Egea, Emilio, Walker, Ryan, Ziauddeen, Hisham, Cardinal, Rudolf N, Bullmore, Edward T
Format: Article
Language:English
Subjects:
Age
Antipsychotic Agents - adverse effects
Birth Weight
Body Mass Index
Cardiovascular and Metabolic Risk
Clinical medicine
Diabetes
Diabetes Mellitus - drug therapy
Diabetes Mellitus - epidemiology
Diabetes Mellitus - genetics
Humans
Hypotheses
Metabolism
Patients
Population
Primary care
Psychotropic drugs
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - epidemiology
Schizophrenia - genetics
Survival analysis
Variables
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Summary:IntroductionThe prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation.ObjectiveTo test if abnormal birth weight (either too low or too high) and parental diabetes, both variables that can be ascertained in the clinic, can predict diabetes onset in patients with schizophrenia.Research design and methodsElectronic records of a cohort of 190 clozapine-treated patients (37% treated for more than 20 years) and Cox regression survival analysis (with any type of glucose dysregulation as the event) to account for differences in length of treatment before the event and age at clozapine treatment initiation.ResultsAge at clozapine initiation (Exp(B)=1.098; p
ISSN:2052-4897
2052-4897
DOI:10.1136/bmjdrc-2019-001036