Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model

Following injury to a tendon little is known about potential for pathology to develop in other regional tendons from overloading or altered function. The aim of this study was to investigate the gene expression and histopathological changes that occur 1) within the deep digital flexor tendon (DDFT)...

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Bibliographic Details
Published in:PloS one 2019-04, Vol.14 (4), p.e0215830-e0215830
Main Authors: Tsang, Albert S, Dart, Andrew J, Biasutti, Sara A, Jeffcott, Leo B, Smith, Margaret M, Little, Christopher B
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Collagen
Collagen - genetics
Development and progression
Disease Models, Animal
Extremities - physiopathology
Gene expression
Gene Expression Regulation - genetics
Genes
Genetic testing
Histochemistry
Humans
Polymerase chain reaction
Sheep
Sheep, Domestic - genetics
Sports injuries
Surgery
Tendinopathy - genetics
Tendinopathy - physiopathology
Tendon injuries
Tendon Injuries - genetics
Tendon Injuries - physiopathology
Tendons - metabolism
Tendons - physiopathology
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Summary:Following injury to a tendon little is known about potential for pathology to develop in other regional tendons from overloading or altered function. The aim of this study was to investigate the gene expression and histopathological changes that occur 1) within the deep digital flexor tendon (DDFT) after injury to the superficial digital flexor tendon (SDFT) and 2) within the flexor tendons (SDFT and DDFT) after injury to the extensor tendons. Merino wethers [Ovis aries] (n = 18) were divided into three equal groups and underwent either partial transection of the SDFT, complete transection of the extensor tendons or were left as non-operated controls. Tendons were harvested and sampled regionally for gene expression (real time PCR) and histologic analysis eight weeks after surgery. Transection of the SDFT resulted in increased expression of collagen III, versican, biglycan, lumican and MMP1 (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0215830