Reduced mechanical function of the left atrial predicts adverse outcome in pregnant women with clustering of metabolic risk factors

• Published in: BMC cardiovascular disorders 2021-05, Vol.21 (1), p.265-265, Article 265
• Main Authors: Ye, Xiaoguang, Li, Zhitian, Li, Yidan, Cai, Qizhe, Sun, Lanlan, Zhu, Weiwei, Ding, Xueyan, Guo, Dichen, Qin, Yunyun, Lu, Xiuzhang
• Format: Article
• Language: English
• Subjects: Abruptio Placentae - diagnosis; Abruptio Placentae - etiology; Abruptio Placentae - physiopathology; Adult; Atrial Function, Left; Blood pressure; Body mass index; Cardiac function; Cardiometabolic Risk Factors; Contraction; Demographic aspects; Diabetes mellitus; Diabetes, Gestational - diagnosis; Diabetes, Gestational - physiopathology; Diagnosis; Disease; Echocardiography; Ejection fraction; Female; Fetal Distress - diagnosis; Fetal Distress - etiology; Fetal Distress - physiopathology; Fetuses; Forecasts and trends; Gestational diabetes; Glucose; Health aspects; Heart Atria - diagnostic imaging; Heart Atria - physiopathology; Heart atrium; Humans; Hypertension; Hypertension, Pregnancy-Induced - diagnosis; Hypertension, Pregnancy-Induced - physiopathology; Left atrial function; Mechanical properties; Medical examination; Metabolic diseases; Metabolic disorders; Metabolic risk factors; Overweight; Patients; Physiology; Placenta; Pre-eclampsia; Predictive Value of Tests; Preeclampsia; Pregnancy; Pregnancy Outcome; Pregnancy, Complications of; Premature Birth; Retrospective Studies; Risk Assessment; Risk factors; Software; Statistical analysis; Womens health
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-021-02082-7

The left atrial (LA) strain and strain rate are sensitive indicators of LA function. However, they are not widely used for the evaluation of pregnant women with metabolic diseases. The aim of this study was to assess the LA strain and strain rate of pregnant women with clustering of metabolic risk factors and to explore its prognostic effect on adverse pregnancy outcomes. Sixty-three pregnant women with a clustering of metabolic risk factors (CMR group), fifty-seven women with pregnancy-induced hypertension (PIH group), fifty-seven women with gestational diabetes mellitus (GDM group), and fifty matched healthy pregnant women (control group) were retrospectively evaluated. LA function was evaluated with two-dimensional speckle-tracking imaging. Iatrogenic preterm delivery caused by severe preeclampsia, placental abruption, and fetal distress was regarded as the primary adverse outcome. The CMR group showed the lowest LA strain during reservoir phase (LASr), strain during contraction phase (LASct) and peak strain rate during conduit phase (pLASRcd) among the three groups (P