Kinematic network of joint motion provides insight on gait coordination: An observational study on Parkinson's disease

• Published in: Heliyon 2024-08, Vol.10 (15), p.e35751, Article e35751
• Main Authors: Troisi Lopez, Emahnuel, Liparoti, Marianna, Minino, Roberta, Romano, Antonella, Polverino, Arianna, Carotenuto, Anna, Tafuri, Domenico, Sorrentino, Giuseppe, Sorrentino, Pierpaolo
• Format: Article
• Language: English
• Subjects: Coordination; Gait; Kinectome; Kinematics; Network; Parkinson's disease
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e35751

The analysis of gait kinematics requires to encode and collapse multidimensional information from multiple anatomical elements. In this study, we address this issue by analyzing the joints' coordination during gait, borrowing from the framework of network theory. We recruited twenty-three patients with Parkinson's disease and twenty-three matched controls that were recorded during linear gait using a stereophotogrammetric motion analysis system. The three-dimensional angular velocity of the joints was used to build a kinematic network for each participant, and both global (average whole-body synchronization) and nodal (individual joint synchronization, i.e., nodal strength) were extracted. By comparing the two groups, the results showed lower coordination in patients, both at global and nodal levels (neck, shoulders, elbows, and hips). Furthermore, the nodal strength of the left elbow and right hip in the patients, as well as the average joints' nodal strength were significantly correlated with the clinical motor condition and were predictive of it. Our study highlights the importance of integrating whole-body information in kinematic analyses and the advantages of using network theory. Finally, the identification of altered network properties of specific joints, and their relationship with the motor impairment in the patients, suggests a potential clinical relevance for our approach. •Network theory allows to manage multiple degrees of freedom to assess coordination.•The aim was to demonstrate how Parkinson's disease impacts joint coordination during walking•Our approach aims to examine global and nodal (joint-specific) features of the kinematic networks•Results highlight the clinical relevance of a network-based approach to analyze gait coordination