CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19

Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to get safe, effective, and affordable COVID-19 treatments quickly is to repurpose drugs that are already approved for other diseases. The proc...

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Bibliographic Details
Published in:Data (Basel) 2022-11, Vol.7 (11), p.164
Main Authors: Jain, Hardik A, Agarwal, Vinti, Bansal, Chaarvi, Kumar, Anupama, Faheem, Mohammed, Muzaffar-Ur-Rehman, Murugesan, Sankaranarayanan, Simpson, Moana M, Karpe, Avinash V, Chandra, Rohitash, MacRaild, Christopher A, Styles, Ian K, Peterson, Amanda L, Cooper, Matthew A, Kirkpatrick, Carl M. J, Shah, Rohan M, Palombo, Enzo A, Trevaskis, Natalie L, Creek, Darren J, Vasan, Seshadri S
Format: Article
Language:English
Subjects:
Candidates
Clinical trials
Concurrency control
Contraindications
Coronaviruses
COVID-19
Data base management systems
Datasets
Design
drug fingerprints
drug repurposing
Drugs
Hydrogen bonds
Medical research
open-source dataset
R&D
Regulatory approval
Research & development
search engine
Severe acute respiratory syndrome coronavirus 2
Software
Viral diseases
web application development
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Summary:Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to get safe, effective, and affordable COVID-19 treatments quickly is to repurpose drugs that are already approved for other diseases. The process of developing an accurate and standardized drug repurposing dataset requires considerable resources and expertise due to numerous commercially available drugs that could be potentially used to address the SARS-CoV-2 infection. To address this bottleneck, we created the CoviRx.org platform. CoviRx is a user-friendly interface that allows analysis and filtering of large quantities of data, which is onerous to curate manually for COVID-19 drug repurposing. Through CoviRx, the curated data have been made open source to help combat the ongoing pandemic and encourage users to submit their findings on the drugs they have evaluated, in a uniform format that can be validated and checked for integrity by authenticated volunteers. This article discusses the various features of CoviRx, its design principles, and how its functionality is independent of the data it displays. Thus, in the future, this platform can be extended to include any other disease beyond COVID-19.
ISSN:2306-5729
2306-5729
DOI:10.3390/data7110164