Diffuse Large B-cell Lymphoma of the Uterus: A Propensity Score Matched Analysis of the Texas Cancer Registry

• Published in: Hematology reports 2020-09, Vol.12 (s1)
• Main Authors: A. Ensor, J. Ensor, K. Anand
• Format: Article
• Language: English
• ISSN: 2038-8322; 2038-8330

Introduction: Primary malignant lymphoma of the uterus is rare. Among such cases, extra-nodal diffuse large B-cell lymphoma (DLBCL) is the most common. Most of the epidemiology and prognosis for uterine DLBCL is derived from case reports and series. The main objective of this research was to compare survival between females with primary uterine DLBCL to females with primary malignant DLBCL of other sites. Methods: We retrospectively queried incidence files of the Texas Cancer Registry from 1997-2017 for women with DLBCL. To address factors that can confound survival analysis, propensity score matching (PSM) was used to balance the two cohorts of interest with respect to stage, treatment, race and age at diagnosis. The survival difference between the two cohorts was investigated using a Cox proportional hazards model based on the robust sandwich estimate for the covariance matrix to account for the dependent nature of the matching process. Results: We identified 12,444 female primary DLBCL cases of which 32 were of the uterus. Post 40:1 PSM, we compared 26 uterine to 1,040 other cases. The distributions of stage (p=0.0008), race (p=0.03), and age (p