Bone Microenvironment and Osteosarcoma Metastasis

The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is closely related to the bone microenvironment. Especially, the metastasis of osteosarcoma is the remaining challenge of therapy...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-10, Vol.21 (19), p.6985
Main Authors: Yang, Chaofei, Tian, Ye, Zhao, Fan, Chen, Zhihao, Su, Peihong, Li, Yu, Qian, Airong
Format: Article
Language:English
Subjects:
Acidosis
Angiogenesis
Animals
Biomedical materials
Bone cancer
Bone marrow
bone microenvironment
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Bone Neoplasms - therapy
Bone tumors
Cancer therapies
Cell cycle
Chemokines
Crosstalk
Cytokines
Development and progression
Drug resistance
Extracellular matrix
Fibroblasts
Gene expression
Humans
Hypoxia
Metabolism
Metastases
Metastasis
Microenvironments
Neoplasm Metastasis
Observations
Osteosarcoma
Osteosarcoma - metabolism
Osteosarcoma - pathology
Osteosarcoma - therapy
Oxidative stress
primary bone tumor
Review
Sarcoma
signal pathway
Signal Transduction
Stem cells
Tumor Microenvironment
Tumors
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Summary:The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is closely related to the bone microenvironment. Especially, the metastasis of osteosarcoma is the remaining challenge of therapy and poor prognosis. Increasing evidence focuses on the relationship between the bone microenvironment and osteosarcoma metastasis. Many elements exist in the bone microenvironment, such as acids, hypoxia, and chemokines, which have been verified to affect the progression and malignance of osteosarcoma through various signaling pathways. We thoroughly summarized all these regulators in the bone microenvironment and the transmission cascades, accordingly, attempting to furnish hints for inhibiting osteosarcoma metastasis via the amelioration of the bone microenvironment. In addition, analysis of the cross-talk between the bone microenvironment and osteosarcoma will help us to deeply understand the development of osteosarcoma. The cellular and molecular protagonists presented in the bone microenvironment promoting osteosarcoma metastasis will accelerate the exploration of novel therapeutic strategies towards osteosarcoma.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21196985