Signaling Induced by Chronic Viral Hepatitis: Dependence and Consequences

Chronic viral hepatitis is a main cause of liver disease and hepatocellular carcinoma. There are striking similarities in the pathological impact of hepatitis B, C, and D, although these diseases are caused by very different viruses. Paired with the conventional study of protein-host interactions, t...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-03, Vol.23 (5), p.2787
Main Authors: Boulahtouf, Zakaria, Virzì, Alessia, Baumert, Thomas F, Verrier, Eloi R, Lupberger, Joachim
Format: Article
Language:English
Subjects:
Antigens
Antioxidants
Bioinformatics
Carcinoma, Hepatocellular - pathology
Chlamydia Infections
Cytochrome
Enzymes
Gene expression
Genomes
HBV
HCV
HDV
Hepatitis B
Hepatitis B - complications
Hepatitis B virus
Hepatitis C
Hepatitis Delta Virus
Hepatitis, Chronic - complications
Hepatitis, Viral, Human - complications
Hepatocellular carcinoma
Human health and pathology
Humans
Hépatology and Gastroenterology
Infections
inflammation
Kinases
Life Sciences
Liver
Liver cancer
Liver diseases
Liver Neoplasms - pathology
Metabolism
Mitochondria
Oxidative stress
Phosphorylation
Proteins
Review
Similarity
Vaccines
Viral infections
Viruses
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Summary:Chronic viral hepatitis is a main cause of liver disease and hepatocellular carcinoma. There are striking similarities in the pathological impact of hepatitis B, C, and D, although these diseases are caused by very different viruses. Paired with the conventional study of protein-host interactions, the rapid technological development of -omics and bioinformatics has allowed highlighting the important role of signaling networks in viral pathogenesis. In this review, we provide an integrated look on the three major viruses associated with chronic viral hepatitis in patients, summarizing similarities and differences in virus-induced cellular signaling relevant to the viral life cycles and liver disease progression.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23052787