Injectable agents for the induction of Peyronie's disease in model rats: a comparative study

Peyronie's disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages. In this study, we aimed to compare four injectable induction agents for the establishment of a robust rat model of PD: transforming...

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Bibliographic Details
Published in:Asian journal of andrology 2025-01, Vol.27 (1), p.96-100
Main Authors: Du, Guang-Jun, Xing, Si-Yan, Wu, Ning, Wang, Tong, Jiang, Yue-Hui, Song, Tao, Yang, Bai-Bing, Dai, Yu-Tian
Format: Article
Language:English
Subjects:
Animals
China
Disease Models, Animal
Diseases
Fibrin
Injections
Male
Penile Induration - drug therapy
Penile Induration - pathology
Penis
Penis - drug effects
Penis - pathology
peyronie’s disease
Physiological aspects
polidocanol
Polidocanol - administration & dosage
Polyethylene Glycols - administration & dosage
rat model
Rats
Rats, Sprague-Dawley
sodium tetradecyl sulfate
Sulfates
tgf-β1
Transforming Growth Factor beta1 - metabolism
Transforming growth factors
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Summary:Peyronie's disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages. In this study, we aimed to compare four injectable induction agents for the establishment of a robust rat model of PD: transforming growth factor-β1 (TGF-β1), fibrin, sodium tetradecyl sulfate (STS) combined with TGF-β1, and polidocanol (POL) combined with TGF-β1. The results showed that injection of TGF-β1 or fibrin into the tunica albuginea induced pathological endpoints without causing penile curvature. The STS + TGF-β1 combination resulted in both histological and morphological alterations, but with a high incidence of localized necrosis that led to animal death. The POL + TGF-β1 combination produced pathological changes and curvature comparable to STS + TGF-β1 and led to fewer complications. In conclusion, fibrin, STS + TGF-β1, and POL + TGF-β1 all induced PD with a certain degree of penile curvature and histological fibrosis in rats. The POL + TGF-β1 combination offered comparatively greater safety and clinical relevance and may have the greatest potential for PD research using model rats.
ISSN:1745-7262
1008-682X
1745-7262
1008-682X
DOI:10.4103/aja202430