Injectable agents for the induction of Peyronie's disease in model rats: a comparative study

Peyronie's disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages. In this study, we aimed to compare four injectable induction agents for the establishment of a robust rat model of PD: transforming...

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Published in:Asian journal of andrology 2025-01, Vol.27 (1), p.96-100
Main Authors: Du, Guang-Jun, Xing, Si-Yan, Wu, Ning, Wang, Tong, Jiang, Yue-Hui, Song, Tao, Yang, Bai-Bing, Dai, Yu-Tian
Format: Article
Language:English
Subjects:
Animals
China
Disease Models, Animal
Diseases
Fibrin
Injections
Male
Penile Induration - drug therapy
Penile Induration - pathology
Penis
Penis - drug effects
Penis - pathology
peyronie’s disease
Physiological aspects
polidocanol
Polidocanol - administration & dosage
Polyethylene Glycols - administration & dosage
rat model
Rats
Rats, Sprague-Dawley
sodium tetradecyl sulfate
Sulfates
tgf-β1
Transforming Growth Factor beta1 - metabolism
Transforming growth factors
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container_end_page 100
container_issue 1
container_start_page 96
container_title Asian journal of andrology
container_volume 27
creator Du, Guang-Jun
Xing, Si-Yan
Wu, Ning
Wang, Tong
Jiang, Yue-Hui
Song, Tao
Yang, Bai-Bing
Dai, Yu-Tian
description Peyronie's disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages. In this study, we aimed to compare four injectable induction agents for the establishment of a robust rat model of PD: transforming growth factor-β1 (TGF-β1), fibrin, sodium tetradecyl sulfate (STS) combined with TGF-β1, and polidocanol (POL) combined with TGF-β1. The results showed that injection of TGF-β1 or fibrin into the tunica albuginea induced pathological endpoints without causing penile curvature. The STS + TGF-β1 combination resulted in both histological and morphological alterations, but with a high incidence of localized necrosis that led to animal death. The POL + TGF-β1 combination produced pathological changes and curvature comparable to STS + TGF-β1 and led to fewer complications. In conclusion, fibrin, STS + TGF-β1, and POL + TGF-β1 all induced PD with a certain degree of penile curvature and histological fibrosis in rats. The POL + TGF-β1 combination offered comparatively greater safety and clinical relevance and may have the greatest potential for PD research using model rats.
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ispartof Asian journal of andrology, 2025-01, Vol.27 (1), p.96-100
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1008-682X
language eng
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source PubMed Central
subjects Animals
China
Disease Models, Animal
Diseases
Fibrin
Injections
Male
Penile Induration - drug therapy
Penile Induration - pathology
Penis
Penis - drug effects
Penis - pathology
peyronie’s disease
Physiological aspects
polidocanol
Polidocanol - administration & dosage
Polyethylene Glycols - administration & dosage
rat model
Rats
Rats, Sprague-Dawley
sodium tetradecyl sulfate
Sulfates
tgf-β1
Transforming Growth Factor beta1 - metabolism
Transforming growth factors
title Injectable agents for the induction of Peyronie's disease in model rats: a comparative study
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