Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human

Myxomatous mitral valve disease is the single most important mitral valve disease in both dogs and humans. In the case of the dog it is ubiquitous, such that all aged dogs will have some evidence of the disease, and for humans it is known as Barlow's disease and affects up to 3% of the populati...

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Bibliographic Details
Published in:Veterinary sciences 2017-07, Vol.4 (3), p.34
Main Authors: Markby, Greg R, Summers, Kim M, MacRae, Vicky E, Corcoran, Brendan M
Format: Article
Language:English
Subjects:
Barlow’s disease
canine
Collagen
Degeneration
Disease
Dogs
Extracellular matrix
Fibrosis
Gene expression
Heparan sulfate
human
Mitral valve
myxomatous mitral valve disease
Pathology
Review
Rheumatic heart disease
Studies
transcriptomic profiling
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Summary:Myxomatous mitral valve disease is the single most important mitral valve disease in both dogs and humans. In the case of the dog it is ubiquitous, such that all aged dogs will have some evidence of the disease, and for humans it is known as Barlow's disease and affects up to 3% of the population, with an expected increase in prevalence as the population ages. Disease in the two species show many similarities and while both have the classic myxomatous degeneration only in humans is there extensive fibrosis. This dual pathology of the human disease markedly affects the valve transcriptome and the difference between the dog and human is dominated by changes in genes associated with fibrosis. This review will briefly examine the comparative valve pathology and then, in more detail, the transcriptomic profiling and gene expression reported so far for both species.
ISSN:2306-7381
2306-7381
DOI:10.3390/vetsci4030034