Enhanced Triacylglycerol Content and Gene Expression for Triacylglycerol Metabolism, Acyl-Ceramide Synthesis, and Corneocyte Lipid Formation in the Epidermis of Borage Oil Fed Guinea Pigs

Triacylglycerol (TAG) metabolism is related to the acyl-ceramide (Cer) synthesis and corneocyte lipid envelope (CLE) formation involved in maintaining the epidermal barrier. Prompted by the recovery of a disrupted epidermal barrier with dietary borage oil (BO: 40.9% linoleic acid (LNA) and 24.0% γ-l...

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Bibliographic Details
Published in:Nutrients 2019-11, Vol.11 (11), p.2818
Main Authors: Lee, Ju-Young, Liu, Kwang-Hyeon, Cho, Yunhi, Kim, Kun-Pyo
Format: Article
Language:English
Subjects:
acyl-ceramide
Acyltransferase
borage oil
Ceramide
Communication
corneocyte lipid envelope
Covalent bonds
Diet
Dioxygenase
Enzymes
Epidermis
Esterification
Fatty acids
Gene expression
Genes
Glycerol
Glycerophosphate
Guinea pigs
Homeostasis
Lipids
Metabolism
Nutrition research
Permeability
Software
triacylglycerol metabolism
Triglycerides
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Summary:Triacylglycerol (TAG) metabolism is related to the acyl-ceramide (Cer) synthesis and corneocyte lipid envelope (CLE) formation involved in maintaining the epidermal barrier. Prompted by the recovery of a disrupted epidermal barrier with dietary borage oil (BO: 40.9% linoleic acid (LNA) and 24.0% γ-linolenic acid (GLA)) in essential fatty acid (EFA) deficiency, lipidomic and transcriptome analyses and subsequent quantitative RT-PCR were performed to determine the effects of borage oil (BO) on TAG content and species, and the gene expression related to overall lipid metabolism. Dietary BO for 2 weeks in EFA-deficient guinea pigs increased the total TAG content, including the TAG species esterified LNA, GLA, and their C20 metabolized fatty acids. Moreover, the expression levels of genes in the monoacylglycerol and glycerol-3-phosphate pathways, two major pathways of TAG synthesis, increased, along with those of TAG lipase, acyl-Cer synthesis, and CLE formation. Dietary BO enhanced TAG content, the gene expression of TAG metabolism, acyl-Cer synthesis, and CLE formation.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11112818