Identification of Prognostic and Predictive Osteosarcoma Biomarkers

Both adolescents and children suffer from osteosarcoma, localized in the metaphysis of the long bones. This is the most common primary high-grade bone tumor in this patient group. Early tumor detection is the key to ensuring effective treatment. Improved osteosarcoma outcomes in clinical trials have...

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Bibliographic Details
Published in:Medical sciences (Basel) 2019-02, Vol.7 (2), p.28
Main Authors: Zamborsky, Radoslav, Kokavec, Milan, Harsanyi, Stefan, Danisovic, Lubos
Format: Article
Language:English
Subjects:
Antibodies
Biomarkers
Bone cancer
Cancer therapies
Cell cycle
Chemotherapy
Clinical trials
Cytokines
DNA methylation
Gene expression
Growth factors
malignant bone tumors
Medical prognosis
Metastasis
MicroRNAs
osteosarcoma
Pediatrics
Review
Stem cells
treatment
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Summary:Both adolescents and children suffer from osteosarcoma, localized in the metaphysis of the long bones. This is the most common primary high-grade bone tumor in this patient group. Early tumor detection is the key to ensuring effective treatment. Improved osteosarcoma outcomes in clinical trials have been contingent on biomarker discovery and an evolving understanding of molecules and their complex interactions. In this review, we present a short overview of biomarkers for osteosarcoma, and highlight advances in osteosarcoma-related biomarker research. Many studies show that several biomarkers undergo critical changes with osteosarcoma progression. Growing knowledge about osteosarcoma-related markers is expected to positively impact the development of therapeutics for osteosarcoma, and ultimately of clinical care. It has also become important to develop new biomarkers, which can identify vulnerable patients who should be treated with more intensive and aggressive therapy after diagnosis.
ISSN:2076-3271
2076-3271
DOI:10.3390/medsci7020028