Changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants

Literature supports an association between transfusions and gut injury in preterm infants. We hypothesized that packed red blood (PRBC) transfusions are associated with kidney inflammation marked by a rise in urinary levels of Kidney Injury Molecule 1 (KIM-1). Prospectively, KIM-1 levels were measur...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2021-06, Vol.11 (1), p.11690-11690, Article 11690
Main Authors: Turner, Stephanie S., Davidson, Jennifer M., Elabiad, Mohamad T.
Format: Article
Language:English
Subjects:
692/4022
692/420/256
692/699/1503
Birth weight
Blood transfusion
Hematocrit
Humanities and Social Sciences
Infants
Inflammation
Kidneys
multidisciplinary
Neonates
Newborn babies
Premature babies
Science
Science (multidisciplinary)
Transfusion
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Literature supports an association between transfusions and gut injury in preterm infants. We hypothesized that packed red blood (PRBC) transfusions are associated with kidney inflammation marked by a rise in urinary levels of Kidney Injury Molecule 1 (KIM-1). Prospectively, KIM-1 levels were measured before and then at 6, 12 and 24 h after a PRBC transfusion. Results are presented as mean (± SD) and median (IQR). Thirty-four infants, birth weight 865 (± 375) g, had higher pretransfusion KIM-1 levels of 2270 (830, 3250) pg/mg than what is normal for age. These were not associated with hematocrit levels. KIM-1 levels peaked between 6 and 12 h after the transfusion. Levels peaked to 3300 (1990, 6830) pg/mg; levels returned to pretransfusion levels of 2240 (1240, 3870) pg/mg by 24 h, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-91209-z