Thermal Preconditioning Alters the Stability of Hump-Snout Whitefish (Coregonus fluviatilis) and Its Hybrid Form, Showing Potential for Aquaculture

• Published in: Biology (Basel, Switzerland) Switzerland), 2023-10, Vol.12 (10), p.1348
• Main Authors: Sapozhnikova, Yulia P, Koroleva, Anastasia G, Yakhnenko, Vera M, Volkova, Aleksandra A, Avezova, Tatyana N, Glyzina, Olga Yu, Sakirko, Mariya V, Tolstikova, Lyubov I, Sukhanova, Lyubov V
• Format: Article
• Language: English
• Subjects: Adaptation; Aging; Aquaculture; Aquaculture industry; Aquatic animals; Biomarkers; Cell division; Climate change; Climatic changes; Cold; Coregonus; Delayed response; Eggs; Environmental conditions; Fish; Fish-culture; Fishes; functionally active mitochondria; Heat shock; Hybrids; Juveniles; Leukocytes; Liver; Mitochondria; Ontogeny; Oxidative stress; Phenolphthalein; Physiology; Plasticity; preconditioning; Senescence; Sperm; stress-induced senescence; Telomerase; Telomeres; Temperature; thermal acclimation
• ISSN: 2079-7737; 2079-7737
• DOI: 10.3390/biology12101348

One of the little-studied ways that climate warming or temperature increases in aquaculture could affect aquatic animals is through accelerated aging. This study is dedicated to understanding the principles of molecular and cellular aging in the target tissues of juvenile whitefishes (Yenisei hump-snout whitefish and its hybrid) under the influence of acute heat stress (up to 26 °C), and the effects of thermal preconditioning as pre-adaptation. Non-adapted stressed hump-snout whitefish showed a higher induction threshold for functionally active mitochondria in the blood and a decrease in telomerase activity in the liver after heat shock exposure as a long-term compensatory response to prevent telomere shortening. However, we observed heat-induced telomere shortening in non-adapted hybrids, which can be explained by a decrease in mitochondrial membrane stability and a gradual increase in energy demand, leading to a decrease in protective telomerase activity. The pre-adapted groups of hump-snout whitefish and hybrids showed a long-term or delayed response of telomerase activity to heat shock, which served as a therapeutic mechanism against telomere shortening. We concluded that the telomerase and telomere responses to thermal stress demonstrate plasticity of tolerance limits and greater stability in hump-snout whitefish compared with hybrids.