Over-Representation of Torque Teno Mini Virus 9 in a Subgroup of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disorder classified by the WHO as postviral fatigue syndrome (ICD-11 8E49 code). Diagnosing ME/CFS, often overlapping with fibromyalgia (FM), is challenging due to nonspecific symptoms and lack of biomarkers. The etiology of ME...

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Bibliographic Details
Published in:Pathogens (Basel) 2024-09, Vol.13 (9), p.751
Main Authors: Giménez-Orenga, Karen, Martín-Martínez, Eva, Oltra, Elisa
Format: Article
Language:English
Subjects:
Anellovirus
Betatorquetevirus family
Biobanks
Biomarkers
Chronic fatigue syndrome
Development and progression
Encephalomyelitis
Epigenetics
Fatigue
Females
Fibromyalgia
Health aspects
Health care
Immune system
Immunology
Infection
ME/CFS
Medical research
Medicine, Experimental
microarray
Patients
Questionnaires
RNA
Subgroups
Torque
TTMV
Viral infections
Viruses
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Summary:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disorder classified by the WHO as postviral fatigue syndrome (ICD-11 8E49 code). Diagnosing ME/CFS, often overlapping with fibromyalgia (FM), is challenging due to nonspecific symptoms and lack of biomarkers. The etiology of ME/CFS and FM is poorly understood, but evidence suggests viral infections play a critical role. This study employs microarray technology to quantitate viral RNA levels in immune cells from ME/CFS, FM, or co-diagnosed cases, and healthy controls. The results show significant overexpression of the Torque Teno Mini Virus 9 (TTMV9) in a subgroup of ME/CFS patients which correlate with abnormal HERV and immunological profiles. Increased levels of TTMV9 transcripts accurately discriminate this subgroup of ME/CFS patients from the other study groups, showcasing its potential as biomarker for patient stratification and the need for further research into its role in the disease. Validation of the findings seems granted in extended cohorts by continuation studies.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens13090751