Dual optofluidic distributed feedback dye lasers for multiplexed biosensing applications

Integrated optofluidic devices have become subjects of high interest for rapid biosensor devices due to their unique ability to combine the fluidic processing of small volumes of microfluidics with the analysis capabilities of photonic structures. By integrating dynamically reconfigurable optofluidi...

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Bibliographic Details
Published in:Scientific reports 2023-10, Vol.13 (1), p.16824-16824, Article 16824
Main Authors: Sano, Tyler, Losakul, Ravipa, Schmidt, Holger
Format: Article
Language:English
Subjects:
639/624
639/624/1075/1079
Biomarkers
Biosensors
Coloring Agents
Dimethyl sulfoxide
Ethylene glycol
Feedback
Humanities and Social Sciences
Humans
Lasers
Lasers, Dye
Microfluidics
Microspheres
multidisciplinary
Optics and Photonics
Polydimethylsiloxane
Rhodamine 6G
Science
Science (multidisciplinary)
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Summary:Integrated optofluidic devices have become subjects of high interest for rapid biosensor devices due to their unique ability to combine the fluidic processing of small volumes of microfluidics with the analysis capabilities of photonic structures. By integrating dynamically reconfigurable optofluidic lasers on-chip, complex coupling can be eliminated while further increasing the capabilities of sensors to detect an increasing number of target biomarkers. Here, we report a polydimethylsiloxane-based device with two on-chip fluidic distributed feedback (DFB) laser cavities that are integrated with an orthogonal analyte channel for multiplexed fluorescence excitation. One DFB grating is filled with 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4 H -pyran dissolved in dimethyl sulfoxide. The second grating is filled with rhodamine 6G dissolved in a diluted ethylene glycol solution. We present characterization of both lasers through analysis of the lasing spectra for spectral narrowing along with a power series to observe threshold behavior. We then demonstrate simultaneous detection of two different fluorescent microbeads as a proof of concept for scalable, single biomarker analysis using on-chip optofluidic lasers.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-42671-4