Two C23-Steroids and a New Isocoumarin Metabolite from Mangrove Sediment-Derived Fungus Penicillium sp. SCSIO 41429

Two new C23-steroids derivatives, cyclocitrinoic acid A (1) and cyclocitrinoic acid B (2), and a new isocoumarin metabolite, (3R,4S)-6,8-dihydroxy-3,4,5-trimethyl-7-carboxamidelisocoumarin (10), together with 12 known compounds (3–9, 11–15) were isolated from the mangrove-sediment fungus Penicillium...

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Bibliographic Details
Published in:Marine drugs 2024-08, Vol.22 (9), p.393
Main Authors: Huang, Lishan, Chen, Chunmei, Cai, Jian, Chen, Yixin, Zhu, Yongyan, Yang, Bin, Zhou, Xuefeng, Liu, Yonghong, Tao, Huaming
Format: Article
Language:English
Subjects:
Acids
antioxidant
Antioxidants
Biological effects
C23-steroid
Carbon
Fungi
isocoumarin
mangrove-sediment fungus
Mangroves
Metabolism
Metabolites
Molecular docking
Natural products
NMR
Nuclear magnetic resonance
Obesity
Oxidative stress
Pancreas
pancreatic lipase (PL)
Penicillium
Scavenging
Sediment
Steroid hormones
Steroids
Weight control
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Summary:Two new C23-steroids derivatives, cyclocitrinoic acid A (1) and cyclocitrinoic acid B (2), and a new isocoumarin metabolite, (3R,4S)-6,8-dihydroxy-3,4,5-trimethyl-7-carboxamidelisocoumarin (10), together with 12 known compounds (3–9, 11–15) were isolated from the mangrove-sediment fungus Penicillium sp. SCSIO 41429. The structures of the new compounds were comprehensively characterized by 1D and 2D NMR, HRESIMS and ECD calculation. All isolates were evaluated for pancreatic lipase (PL) inhibitory and antioxidant activities. The biological evaluation results revealed that compounds 2, 14 and 15 displayed weak or moderate inhibition against PL, with IC50 values of 32.77, 5.15 and 2.42 µM, respectively. In addition, compounds 7, 12 and 13 showed radical scavenging activities against DPPH, with IC50 values of 64.70, 48.13, and 75.54 µM, respectively. In addition, molecular docking results indicated that these compounds had potential for PL inhibitory and antioxidant activities, which provided screening candidates for antioxidants and a reduction in obesity.
ISSN:1660-3397
1660-3397
DOI:10.3390/md22090393