The Role of Cytoskeleton Protein 4.1 in Immunotherapy

Cytoskeleton protein 4.1 is an essential class of skeletal membrane protein, initially found in red blood cells, and can be classified into four types: 4.1R (red blood cell type), 4.1N (neuronal type), 4.1G (general type), and 4.1B (brain type). As research progressed, it was discovered that cytoske...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-02, Vol.24 (4), p.3777
Main Authors: Si, Chaohua, Yuan, Lihua, Chen, Chen, Wang, Ting, Kang, Qiaozhen
Format: Article
Language:English
Subjects:
Antigens
B cells
Cancer
Care and treatment
Cell cycle
Colorectal cancer
Cytoskeleton
cytoskeleton protein 4.1
Dendritic cells
Development and progression
Diagnosis
Erythrocytes
Immune system
Immunoregulation
Immunotherapy
Influence
Lymphocytes
Medical diagnosis
Membrane proteins
Metastasis
Motility
Oncology, Experimental
Protein 4.1
Proteins
Radiation therapy
Review
Signal transduction
Tumor microenvironment
tumor suppressor
Tumor suppressor genes
Tumors
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Summary:Cytoskeleton protein 4.1 is an essential class of skeletal membrane protein, initially found in red blood cells, and can be classified into four types: 4.1R (red blood cell type), 4.1N (neuronal type), 4.1G (general type), and 4.1B (brain type). As research progressed, it was discovered that cytoskeleton protein 4.1 plays a vital role in cancer as a tumor suppressor. Many studies have also demonstrated that cytoskeleton protein 4.1 acts as a diagnostic and prognostic biomarker for tumors. Moreover, with the rise of immunotherapy, the tumor microenvironment as a treatment target in cancer has attracted great interest. Increasing evidence has shown the immunoregulatory potential of cytoskeleton protein 4.1 in the tumor microenvironment and treatment. In this review, we discuss the role of cytoskeleton protein 4.1 within the tumor microenvironment in immunoregulation and cancer development, with the intention of providing a new approach and new ideas for future cancer diagnosis and treatment.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24043777