In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants

• Published in: Anais da Academia Brasileira de Ciências 2011-12, Vol.83 (4), p.1397-1402
• Main Authors: Coy-Barrera, Ericsson D, Cuca-Suarez, Luis E
• Format: Article
• Language: English
• Subjects: 5-LOX; agregação plaquetária; Animals; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; COX; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors - pharmacology; Cyclooxygenase Inhibitors - isolation & purification; Cyclooxygenase Inhibitors - pharmacology; furofuran lignans; Lauraceae - chemistry; lignanos furofurânicos; Lipoxygenase Inhibitors - isolation & purification; Lipoxygenase Inhibitors - pharmacology; MULTIDISCIPLINARY SCIENCES; Ocotea macrophylla; platelet aggregation; Platelet Aggregation Inhibitors - isolation & purification; Platelet Aggregation Inhibitors - pharmacology; Pleurothyrium cinereum; Rabbits
• ISSN: 0001-3765; 1678-2690; 1678-2690
• DOI: 10.1590/S0001-37652011005000044

The in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O-methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor and PAF-antagonist (COX-2 IC(50) 2.27 µM; 5-LOX IC(50) 5.05 µM; PAF IC(50) 2.51 µM). However, all compounds exhibited an activity at different levels, indicating good anti-inflammatory properties to be considered in further structural optimization studies.