New Heteroleptic 3D Metal Complexes: Synthesis, Antimicrobial and Solubilization Parameters

• Published in: Molecules (Basel, Switzerland) Switzerland), 2020-09, Vol.25 (18), p.4252
• Main Authors: Taj, Muhammad Babar, Alkahtani, Muneera D F, Ali, Uzma, Raheel, Ahmad, Alelwani, Walla, Alnajeebi, Afnan M, Babteen, Nouf Abubakr, Noor, Sadia, Alshater, Heba
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; antimicrobial; Cobalt - chemistry; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Copper - chemistry; Electric Conductivity; electronic spectroscopy; Fungi - drug effects; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Ligands; micellar solubilization; Microbial Sensitivity Tests; mixed chelation; Nickel - chemistry; Sodium Dodecyl Sulfate - chemistry; Solubility; Spectrophotometry, Infrared; stability constants; Zinc - chemistry
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25184252

The microbial resistance to current antibiotics is increasing day by day, which in turn accelerating the development of new effective drugs. Several studies have proved the high antimicrobial potential of the interaction of several organic ligands with a variety of metal ions. In the present study, a conventional method has been adopted in the synthesis of twelve new heteroleptic complexes of cobalt (II), nickel (II), copper (II) and zinc (II) using three aldimines, namely, (HL (( )-2-((4-chloro-2-hydroxybenzylidene)amino)-3,4-dimethyl-5-phenylcyclopent-2-en-1-one), HL (( )-3-((4-chlorobenzylidene)amino)-4-hydroxy-5-nitrobenzenesulfonic acid) HL (2,2'-((1,2-phenylenebis(azaneylylidene))bis(methaneylylidene))diphenol)) as primary ligands, while phenyl glycine was the secondary ligand. The synthesized compounds were characterized by UV-vis, IR and multinuclear ( H and C) NMR spectroscopy, elemental analysis, and electrical conductance. The IR study revealed the coordination of the aldimine derivatives with the -OH and N atom of imine moiety. In contrary to this, the phenyl glycine coordinated to the metal ions via oxygen of carboxylate and nitrogen of the amino group. The spectroscopic analysis unveiled the tetrahedral geometry of the synthesized metal (II) complexes, except for ligand HL which exhibited octahedral geometry. The synthesized compounds generally showed antibacterial activity for all microbes, except Ni (II) complexes lacking sensitivity. Furthermore, to access the bioavailability, the synthesized complexes were screened for their solubilization in the micellar media of sodium lauryl sulphate. The metal complex-surfactant interaction was revealed by UV-vis spectroscopy and electrical conductivity measurements.