Caraway Nanoemulsion Gel: A Potential Antibacterial Treatment against Escherichia coli and Staphylococcus aureus

Novel antibiotics are needed due to the rise of antibiotic-resistant pathogens. Traditional antibiotics are ineffective due to antibiotic-resistant microorganisms, and finding alternative therapies is expensive. Hence, plant-derived caraway (Carum carvi) essential oils and antibacterial compounds ha...

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Bibliographic Details
Published in:Gels 2023-03, Vol.9 (3), p.193
Main Authors: Alqarni, Mohammed H, Foudah, Ahmed I, Aodah, Alhussain H, Alkholifi, Faisal K, Salkini, Mohammad Ayman, Alam, Aftab
Format: Article
Language:English
Subjects:
antibacterial
Antibacterial materials
Antibiotics
Bacteria
Bioavailability
caraway essential oil
E coli
Efficiency
Escherichia coli
Essential oils
Gels
Microorganisms
Morphology
nanoemulsion gel
Nanoemulsions
Oils & fats
Particle size
Polydispersity
Skin
Staphylococcus aureus
Surfactants
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Summary:Novel antibiotics are needed due to the rise of antibiotic-resistant pathogens. Traditional antibiotics are ineffective due to antibiotic-resistant microorganisms, and finding alternative therapies is expensive. Hence, plant-derived caraway (Carum carvi) essential oils and antibacterial compounds have been selected as alternatives. In this, caraway essential oil as an antibacterial treatment was investigated using a nanoemulsion gel. Using the emulsification technique, a nanoemulsion gel was developed and characterized in terms of particle size, polydispersity index, pH, and viscosity. The results showed that the nanoemulsion had a mean particle size of 137 nm and an encapsulation efficiency of 92%. Afterward, the nanoemulsion gel was incorporated into the carbopol gel and was found to be transparent and uniform. The gel had in vitro cell viability and antibacterial activity against ( ) and ( ). The gel safely delivered a transdermal drug with a cell survival rate of over 90%. With a minimal inhibitor concentration (MIC) of 0.78 mg/mL and 0.78 mg/mL, respectively, the gel demonstrated substantial inhibition for and . Lastly, the study demonstrated that caraway essential oil nanoemulsion gels can be efficient in treating and , laying the groundwork for the use of caraway essential oil as an alternative to synthetic antibiotics in the treatment of bacterial infections.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels9030193