A reproducible representation of healthy tibiofemoral kinematics during stair descent using REFRAME – Part II: Exploring optimisation criteria and inter-subject differences

• Published in: Scientific reports 2024-10, Vol.14 (1), p.25345-15, Article 25345
• Main Authors: Ortigas-Vásquez, Ariana, Taylor, William R., Postolka, Barbara, Schütz, Pascal, Maas, Allan, Grupp, Thomas M., Sauer, Adrian
• Format: Article
• Language: English
• Subjects: 639/166/985; 692/1537/805; 692/698/1671; Adult; Biomechanical Phenomena; Biomechanics; Female; Femur - physiology; Gait analysis; Humanities and Social Sciences; Humans; Joint coordinate system; Kinematics; Knee; Knee Joint - physiology; Male; Movement - physiology; multidisciplinary; Range of Motion, Articular - physiology; Reference frame; Rotational behavior; Science; Science (multidisciplinary); Stair Climbing - physiology; Tibia - physiology; Tibiofemoral; Translation; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-76275-3

Kinematic analysis is a central component of movement biomechanics, describing the relative motion of joint segments during different activities, in different subject cohorts, and at different timepoints. Establishing whether two sets of kinematic signals represent fundamentally similar or different underlying motion patterns is especially challenging, given 1) the lack of consensus around reference frame and joint axis definition, and 2) the substantial effect that minimal variations in frame position and orientation are known to have on signal magnitude and characteristics. As such, enormous variability in the reporting of tibiofemoral kinematics has resulted in joint movement patterns that remain controversially discussed. Previously, we demonstrated the ability of the REference FRame Alignment MEthod (REFRAME) to reorientate and reposition differently aligned local segment frames to achieve convergence in signals representing the same underlying motion, thereby offering a novel approach to consistently report joint motion. In this study, for the first time, we apply REFRAME to assess the rotational and translational in vivo tibiofemoral motion of ten healthy subjects during stair descent based on kinematic signals collected using a moving videofluoroscope. Kinematics were analysed before and after different REFRAME implementations, revealing generally neutral ab/adduction behaviour, accompanied by varying degrees of a sinusoidal int/external tibial rotation pattern over the activity cycle. Our data demonstrate that different selected implementations of REFRAME are able to highlight different characteristics of the motion patterns: Minimisation of the translational root-mean-square revealed proximodistal translation patterns with overall neutral progression, while anteroposterior translation showed seemingly different levels of correlation with flexion/extension in different subjects. On the other hand, REFRAME minimisation of translational variances exposed differences in the relative mean displacement between the femoral and tibial origins between subjects, highlighting differences in mean centre of rotation positions. This early application of REFRAME for providing an understanding of tibiofemoral kinematics demonstrates the potential of this novel approach to bring clarity to an otherwise complex representation of highly variable time-series signals, while highlighting the philosophical challenges of clinically interpretating kinematic signals in th