Quercetin Synergistically Inhibit EBV-Associated Gastric Carcinoma with Ganoderma lucidum Extracts

• Published in: Molecules (Basel, Switzerland) Switzerland), 2019-10, Vol.24 (21), p.3834
• Main Authors: Huh, Sora, Lee, Seulki, Choi, Su Jin, Wu, Zhexue, Cho, Jae-Han, Kim, Lina, Shin, Yu Su, Kang, Byung Woog, Kim, Jong Gwang, Liu, Kwanghyeon, Cho, Hyosun, Kang, Hyojeung
• Format: Article
• Language: English
• Subjects: Acids; Animals; Antigens; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Antitumor activity; Apoptosis; Apoptosis - drug effects; Cancer; Cell Line, Tumor; Cell proliferation; Chemotherapy; Cytotoxicity; ebv-associated gastric carcinoma; Enzymes; Epstein-Barr virus; Epstein-Barr Virus Infections - drug therapy; Epstein-Barr Virus Infections - metabolism; Epstein-Barr Virus Infections - pathology; Female; Flavonoids; Ganoderic acid; ganoderic acid a; Ganoderma lucidum; ganoderma lucidum extracts; Gastric cancer; Genomes; Herpes viruses; Herpesvirus 4, Human - physiology; HIV; Human immunodeficiency virus; Humans; Low concentrations; Metastases; Mice; Mice, Nude; Mushrooms; Plant Extracts - chemistry; Plant Extracts - pharmacology; Polysaccharides; Proteins; Quercetin; Quercetin - pharmacology; Reishi - chemistry; Saccharides; Signal transduction; Stomach Neoplasms - drug therapy; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Stomach Neoplasms - virology; Telomerase; Triterpenes; Triterpenes - chemistry; Triterpenes - pharmacology; Tumors; Virus Activation - drug effects; Xenografts; Xenotransplantation
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24213834

Mycotherapy has been shown to improve the overall response rate during cancer treatment and reduce some chemotherapy-related adverse events. is a traditional mushroom used for pharmaceutical purposes. extracts (GLE) showed potential antitumor activities against several cancers. These tumor inhibitory effects of GLE were attributed to the suppression of the proliferation and metastasis of cancer cells. Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) is defined as the monoclonal proliferation of carcinoma cells with latent EBV infection. The inhibitory effects of GLE against EBVaGC are questionable. The aim of this study was to investigate GLE as potential antitumor agents and a counterpart of quercetin (QCT) for the cotreatment in suppressing EBVaGC development. Therefore, this study conducted antitumor assays using a EBVaGC xenograft mice model and found that GLE could suppress tumor development. These inhibitory effects were significantly augmented by the low concentration of the quercetin (QCT) cotreatment in the xenograft mice. The addition of GLE in low concentrations synergistically reinforced QCT-induced apoptosis and EBV lytic reactivation. GLE contains various polysaccharides and triterpenes, such as ganoderic acid. Interestingly, the addition of ganoderic acid A (GAA) could produce similar bioactive effects like GLE in QCT-mediated antitumor activity. The GAA addition in low concentrations synergistically reinforced QCT-induced apoptosis and EBV lytic reactivation. GAA was sufficiently effective as much as GLE. Therefore, our results suggested that QCT-supplemented GLE could be a potential food adjunct for the prevention of EBVaGC development.