Association of Retinal Neurovascular Impairment with Disease Severity in Patients with Major Depressive Disorder: An Optical Coherence Tomography Angiography Study

Identifying the fundus objective biomarkers for the major depressive disorders (MDD) may help promote mental health. The aim of this study was to evaluate retinal neurovascular changes and further investigate their association with disease severity in MDD. This cross-sectional study conducted in the...

Full description

Saved in:
Bibliographic Details
Published in:Psychology research and behavior management 2024-01, Vol.17, p.1573-1585
Main Authors: Wang, Yan, Li, Cong, Liu, Lei, Yang, Yuan, He, Xue, Li, Gang, Zheng, Xianzhen, Ren, Yun, Zhao, Hanpeng, Du, Zhenchao, Jiang, Jianrong, Kuang, Yu, Jia, Fujun, Yu, Honghua, Yang, Xiaohong
Format: Article
Language:English
Subjects:
Angiography
Care and treatment
disease severity
Insomnia
Major depressive disorder
Medical research
Medicine, Experimental
Mental health
optical coherence tomography angiography
retinal neurovasculature
Somatotropin
Tomography
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Identifying the fundus objective biomarkers for the major depressive disorders (MDD) may help promote mental health. The aim of this study was to evaluate retinal neurovascular changes and further investigate their association with disease severity in MDD. This cross-sectional study conducted in the hospital enrolled patients with MDD and healthy controls.The retinal neurovascular parameters for all subjects, including vessel density (VD), thickness of ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL), and optic nerve head (ONH) eg are automatically calculated by the software in optical coherence tomography angiography (OCTA). The severity of MDD including depressive symptoms, anxiety, cognition, and insomnia was assessed by Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale (HAMA), Montreal Cognitive Assessment (MoCA), and Insomnia Severity Index (ISI) respectively. This study included 74 MDD patients (n=74 eyes) and 60 healthy controls (HCs) (n=60 eyes). MDD patients showed significantly decreased VD of superficial and deep capillary plexus, thickness of GCC and RNFL, and volume of ONH (all
ISSN:1179-1578
1179-1578
DOI:10.2147/PRBM.S443146