Exosomes in craniofacial tissue reconstruction

Background Mesenchymal stem cell (MSC) therapy gained interest among scientists following the discovery of its therapeutic potential. However, their clinical use has been hindered due to their immunogenicity and tumorigenicity. Relatively recently, it has been unveiled that the mechanism by which MS...

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Bibliographic Details
Published in:Maxillofacial plastic and reconstructive surgery 2022-08, Vol.44 (1), p.27-27, Article 27
Main Authors: Salah, Muhja, Naini, Farhad B.
Format: Article
Language:English
Subjects:
Biogenesis and tissue bone scaffolds
Biosynthesis
Bone tissue engineering
Bones
Cardiomyocytes
Dentistry
Exosomes
Medicine
Mesenchymal stem cells
Oral and Maxillofacial Surgery
Plastic Surgery
Proteins
Reconstructive surgery
Review
Skin & tissue grafts
Stem cells
Tissue engineering
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Summary:Background Mesenchymal stem cell (MSC) therapy gained interest among scientists following the discovery of its therapeutic potential. However, their clinical use has been hindered due to their immunogenicity and tumorigenicity. Relatively recently, it has been unveiled that the mechanism by which MSC promote healing is by secreting exosomes. This raised the interest in developing cell-free therapy, avoiding the obstacles that deterred the translation of MSC therapy into clinical practice. Review This comprehensive narrative review summarises the current understanding of exosome biogenesis and content. Moreover, the existing research on exosome use in bone tissue engineering is discussed. Conclusions Exosome-based therapy may provide excellent potential in the field of bone tissue engineering and craniofacial reconstructive surgery. Further investigation is required before the technology can be translated into clinical practice.
ISSN:2288-8586
2288-8101
2288-8586
DOI:10.1186/s40902-022-00357-3