Fate and freedom in developing neocortical circuits

The activity of neuronal circuits of the neocortex underlies our ability to perceive the world and interact with our environment. During development, these circuits emerge from dynamic interactions between cell-intrinsic, genetically determined programs and input/activity-dependent signals, which to...

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Bibliographic Details
Published in:Nature communications 2017-07, Vol.8 (1), p.16042-16042, Article 16042
Main Author: Jabaudon, Denis
Format: Article
Language:English
Subjects:
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Animals
Brain
Circuits
Gene expression
Gene-Environment Interaction
Genetic engineering
Glutamic Acid - metabolism
Humanities and Social Sciences
Humans
Mice
multidisciplinary
Neocortex
Neocortex - cytology
Neocortex - growth & development
Neocortex - metabolism
Neocortex - physiology
Nerve Net
Neural Pathways
Neurogenesis - genetics
Neuronal Plasticity
Neurons
Neurons - cytology
Neurons - metabolism
Review
review-article
Science
Science (multidisciplinary)
Single-Cell Analysis
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Description
Summary:The activity of neuronal circuits of the neocortex underlies our ability to perceive the world and interact with our environment. During development, these circuits emerge from dynamic interactions between cell-intrinsic, genetically determined programs and input/activity-dependent signals, which together shape these circuits into adulthood. Building on a large body of experimental work, several recent technological developments now allow us to interrogate these nature–nurture interactions with single gene/single input/single-cell resolution. Focusing on excitatory glutamatergic neurons, this review discusses the genetic and input-dependent mechanisms controlling how individual cortical neurons differentiate into specialized cells to assemble into stereotypical local circuits within global, large-scale networks. Proper functioning of the neocortex – the center of higher-order brain functions – depends on the correct assembly of neocortical neural circuits during development. Here the author discusses how cell-intrinsic developmental programs and activity-dependent signals together shape the formation of neocortical circuits.
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms16042