Oxidative stress and radioiodine treatment of differentiated thyroid cancer

It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malond...

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Bibliographic Details
Published in:Scientific reports 2021-08, Vol.11 (1), p.17126-10, Article 17126
Main Authors: Buczyńska, Angelika, Sidorkiewicz, Iwona, Rogucki, Mariusz, Siewko, Katarzyna, Adamska, Agnieszka, Kościuszko, Maria, Maliszewska, Katarzyna, Kozłowska, Gabryela, Szumowski, Piotr, Myśliwiec, Janusz, Dzięcioł, Janusz, Krętowski, Adam, Popławska-Kita, Anna
Format: Article
Language:English
Subjects:
692/163/2743
692/4028/67
692/700/565/485
Female
Humanities and Social Sciences
Humans
Iodine
Iodine radioisotopes
Iodine Radioisotopes - therapeutic use
Male
Malondialdehyde
Malondialdehyde - metabolism
Middle Aged
multidisciplinary
Oxidative Stress
Patients
Radiotherapy - adverse effects
Science
Science (multidisciplinary)
Serum levels
Thyroid
Thyroid cancer
Thyroid Hormones - metabolism
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - radiotherapy
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Summary:It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malondialdehyde (MDA) concentration in patients with differentiated thyroid cancer (DTC) undergoing RAI treatment. Considering the results obtained in the study group, the serum levels of MDA in DTC patients were significantly higher compared to the healthy subjects ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-96637-5