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Oxidative stress and radioiodine treatment of differentiated thyroid cancer
It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malond...
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| Published in: | Scientific reports 2021-08, Vol.11 (1), p.17126-10, Article 17126 |
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| creator | Buczyńska, Angelika Sidorkiewicz, Iwona Rogucki, Mariusz Siewko, Katarzyna Adamska, Agnieszka Kościuszko, Maria Maliszewska, Katarzyna Kozłowska, Gabryela Szumowski, Piotr Myśliwiec, Janusz Dzięcioł, Janusz Krętowski, Adam Popławska-Kita, Anna |
| description | It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malondialdehyde (MDA) concentration in patients with differentiated thyroid cancer (DTC) undergoing RAI treatment. Considering the results obtained in the study group, the serum levels of MDA in DTC patients were significantly higher compared to the healthy subjects (
p
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| doi_str_mv | 10.1038/s41598-021-96637-5 |
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p
< 0.05). The MDA concentration was significantly higher on the third day after RAI (
p
< 0.001) and significantly lower one year after RAI (
p
< 0.05) in DTC patients compared to the baseline concentration. Moreover, the redox stabilization after RAI treatment in patients with DTC during a year-long observation was demonstrated. Accordingly, an increased oxidative stress impact on the related biochemical parameters reflecting the health conditions of the DTC patients was determined. Our study showed that increased oxidative stress reflected by MDA measurements in DTC patients is further enhanced by RAI, but this effect is no longer observed one year after the therapy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-96637-5</identifier><identifier>PMID: 34429481</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743 ; 692/4028/67 ; 692/700/565/485 ; Female ; Humanities and Social Sciences ; Humans ; Iodine ; Iodine radioisotopes ; Iodine Radioisotopes - therapeutic use ; Male ; Malondialdehyde ; Malondialdehyde - metabolism ; Middle Aged ; multidisciplinary ; Oxidative Stress ; Patients ; Radiotherapy - adverse effects ; Science ; Science (multidisciplinary) ; Serum levels ; Thyroid ; Thyroid cancer ; Thyroid Hormones - metabolism ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - radiotherapy</subject><ispartof>Scientific reports, 2021-08, Vol.11 (1), p.17126-10, Article 17126</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-74c029514aa5c3ac34dbf3085ce77782637fd0e34871b4c22beb68290e3469613</citedby><cites>FETCH-LOGICAL-c540t-74c029514aa5c3ac34dbf3085ce77782637fd0e34871b4c22beb68290e3469613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2563935913/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2563935913?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34429481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buczyńska, Angelika</creatorcontrib><creatorcontrib>Sidorkiewicz, Iwona</creatorcontrib><creatorcontrib>Rogucki, Mariusz</creatorcontrib><creatorcontrib>Siewko, Katarzyna</creatorcontrib><creatorcontrib>Adamska, Agnieszka</creatorcontrib><creatorcontrib>Kościuszko, Maria</creatorcontrib><creatorcontrib>Maliszewska, Katarzyna</creatorcontrib><creatorcontrib>Kozłowska, Gabryela</creatorcontrib><creatorcontrib>Szumowski, Piotr</creatorcontrib><creatorcontrib>Myśliwiec, Janusz</creatorcontrib><creatorcontrib>Dzięcioł, Janusz</creatorcontrib><creatorcontrib>Krętowski, Adam</creatorcontrib><creatorcontrib>Popławska-Kita, Anna</creatorcontrib><title>Oxidative stress and radioiodine treatment of differentiated thyroid cancer</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malondialdehyde (MDA) concentration in patients with differentiated thyroid cancer (DTC) undergoing RAI treatment. Considering the results obtained in the study group, the serum levels of MDA in DTC patients were significantly higher compared to the healthy subjects (
p
< 0.05). The MDA concentration was significantly higher on the third day after RAI (
p
< 0.001) and significantly lower one year after RAI (
p
< 0.05) in DTC patients compared to the baseline concentration. Moreover, the redox stabilization after RAI treatment in patients with DTC during a year-long observation was demonstrated. Accordingly, an increased oxidative stress impact on the related biochemical parameters reflecting the health conditions of the DTC patients was determined. Our study showed that increased oxidative stress reflected by MDA measurements in DTC patients is further enhanced by RAI, but this effect is no longer observed one year after the therapy.</description><subject>692/163/2743</subject><subject>692/4028/67</subject><subject>692/700/565/485</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Iodine</subject><subject>Iodine radioisotopes</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - metabolism</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Oxidative Stress</subject><subject>Patients</subject><subject>Radiotherapy - adverse effects</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Serum levels</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid Hormones - metabolism</subject><subject>Thyroid Neoplasms - 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therapeutic use</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - metabolism</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Oxidative Stress</topic><topic>Patients</topic><topic>Radiotherapy - adverse effects</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Serum levels</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid Hormones - metabolism</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buczyńska, Angelika</creatorcontrib><creatorcontrib>Sidorkiewicz, Iwona</creatorcontrib><creatorcontrib>Rogucki, Mariusz</creatorcontrib><creatorcontrib>Siewko, Katarzyna</creatorcontrib><creatorcontrib>Adamska, Agnieszka</creatorcontrib><creatorcontrib>Kościuszko, Maria</creatorcontrib><creatorcontrib>Maliszewska, Katarzyna</creatorcontrib><creatorcontrib>Kozłowska, Gabryela</creatorcontrib><creatorcontrib>Szumowski, Piotr</creatorcontrib><creatorcontrib>Myśliwiec, Janusz</creatorcontrib><creatorcontrib>Dzięcioł, Janusz</creatorcontrib><creatorcontrib>Krętowski, Adam</creatorcontrib><creatorcontrib>Popławska-Kita, Anna</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buczyńska, Angelika</au><au>Sidorkiewicz, Iwona</au><au>Rogucki, Mariusz</au><au>Siewko, Katarzyna</au><au>Adamska, Agnieszka</au><au>Kościuszko, Maria</au><au>Maliszewska, Katarzyna</au><au>Kozłowska, Gabryela</au><au>Szumowski, Piotr</au><au>Myśliwiec, Janusz</au><au>Dzięcioł, Janusz</au><au>Krętowski, Adam</au><au>Popławska-Kita, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress and radioiodine treatment of differentiated thyroid cancer</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2021-08-24</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>17126</spage><epage>10</epage><pages>17126-10</pages><artnum>17126</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malondialdehyde (MDA) concentration in patients with differentiated thyroid cancer (DTC) undergoing RAI treatment. Considering the results obtained in the study group, the serum levels of MDA in DTC patients were significantly higher compared to the healthy subjects (
p
< 0.05). The MDA concentration was significantly higher on the third day after RAI (
p
< 0.001) and significantly lower one year after RAI (
p
< 0.05) in DTC patients compared to the baseline concentration. Moreover, the redox stabilization after RAI treatment in patients with DTC during a year-long observation was demonstrated. Accordingly, an increased oxidative stress impact on the related biochemical parameters reflecting the health conditions of the DTC patients was determined. Our study showed that increased oxidative stress reflected by MDA measurements in DTC patients is further enhanced by RAI, but this effect is no longer observed one year after the therapy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34429481</pmid><doi>10.1038/s41598-021-96637-5</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/163/2743 692/4028/67 692/700/565/485 Female Humanities and Social Sciences Humans Iodine Iodine radioisotopes Iodine Radioisotopes - therapeutic use Male Malondialdehyde Malondialdehyde - metabolism Middle Aged multidisciplinary Oxidative Stress Patients Radiotherapy - adverse effects Science Science (multidisciplinary) Serum levels Thyroid Thyroid cancer Thyroid Hormones - metabolism Thyroid Neoplasms - metabolism Thyroid Neoplasms - radiotherapy |
| title | Oxidative stress and radioiodine treatment of differentiated thyroid cancer |
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