Detecting horizontal gene transfer among microbiota: an innovative pipeline for identifying co-shared genes within the mobilome through advanced comparative analysis

Horizontal gene transfer (HGT) is a key driver in the evolution of bacterial genomes. The acquisition of genes mediated by HGT may enable bacteria to adapt to ever-changing environmental conditions. Long-term application of antibiotics in intensive agriculture is associated with the dissemination of...

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Bibliographic Details
Published in:Microbiology spectrum 2024-01, Vol.12 (1), p.e0196423-e0196423
Main Authors: Schwarzerova, Jana, Zeman, Michal, Babak, Vladimir, Jureckova, Katerina, Nykrynova, Marketa, Varga, Margaret, Weckwerth, Wolfram, Dolejska, Monika, Provaznik, Valentine, Rychlik, Ivan, Cejkova, Darina
Format: Article
Language:English
Subjects:
animal microbiome
Animals
Anti-Bacterial Agents
Bacteria - genetics
Gene Transfer, Horizontal
Genes, Bacterial
genome evolution
Genome, Bacterial
horizontal gene transfer
Host-Microbial Interactions
Microbiota
mobile genetic elements
mobilome
Research Article
resistance genes
Swine
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Summary:Horizontal gene transfer (HGT) is a key driver in the evolution of bacterial genomes. The acquisition of genes mediated by HGT may enable bacteria to adapt to ever-changing environmental conditions. Long-term application of antibiotics in intensive agriculture is associated with the dissemination of antibiotic resistance genes among bacteria with the consequences causing public health concern. Commensal farm-animal-associated gut microbiota are considered the reservoir of the resistance genes. Therefore, in this study, we identified known and not-yet characterized mobilized genes originating from chicken and porcine fecal samples using our innovative pipeline followed by network analysis to provide appropriate visualization to support proper interpretation.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.01964-23