Visual Analysis of Colorectal Cancer Immunotherapy: A Bibliometric Analysis From 2012 to 2021

An increasing number of studies have shown that immunotherapy serves a significant role in treating colorectal cancer (CRC) and has become a hotspot. However, few studies used the bibliometric method to analyze this field comprehensively. This study collected 1,899 records of CRC immunotherapy from...

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Bibliographic Details
Published in:Frontiers in immunology 2022-03, Vol.13, p.843106-843106
Main Authors: Ma, Long, Ma, Jixiang, Teng, Muzhou, Li, Yumin
Format: Article
Language:English
Subjects:
bibliometric
Bibliometrics
CiteSpace
colorectal cancer
Colorectal Neoplasms - therapy
gut microbiota
Humans
immune checkpoint
Immunologic Factors
Immunology
Immunotherapy
Liver Neoplasms
Tumor Microenvironment
United States
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Summary:An increasing number of studies have shown that immunotherapy serves a significant role in treating colorectal cancer (CRC) and has become a hotspot. However, few studies used the bibliometric method to analyze this field comprehensively. This study collected 1,899 records of CRC immunotherapy from 2012 to October 31, 2021, and used CiteSpace to analyze regions, institutions, journals, authors, and keywords to predict the latest trends in CRC immunotherapy research. The United States and China, contributing more than 60% of publications, were the main drivers in this field. Sun Yat-sen University was the most active institution, while the National Cancer Institute had the highest frequency of citations. Most publications were published in the Adam E Snook was the most prolific writer, while Dung T. Le was the most commonly co-cited author. "T cell", "MMI" and "PD-1blocked" were the most widely studied aspects of CRC immunotherapy. "Immune checkpoint inhibitor", "combination therapy", "drug therapy" and "liver metastases" were current research hotspots. "Tumor microenvironment", "neutrophils", "tumor-associated macrophages", and "suppressor cell" have emerged as research hotspots in recent years. "Gut microbiota", "nanoparticle" and "tumor mutational burden" as recently emerged frontiers of research that should be closely monitored.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.843106