Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats

Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome P450 enzymes to form reactive electrophiles that cause ox...

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Published in:Journal of pharmacy & bioallied science 2015-04, Vol.7 (Suppl 1), p.S40-S45
Main Authors: Jayaprakash, R, Ramesh, V, Sridhar, M P, Sasikala, C
Format: Article
Language:English
Subjects:
Albinism
Animals
Antioxidants
cancer
Care and treatment
Chemicals
Cytotoxicity
diethylnitrosamines
Enzymes
Free radicals
Health aspects
Laboratories
Lipids
Liver cancer
Liver diseases
Materia medica, Vegetable
Medical Science
Oxidative stress
Plant extracts
Rodents
Tinospora cordifolia
Vitamin E
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Summary:Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome P450 enzymes to form reactive electrophiles that cause oxidative stress leading to cytotoxicity, mutagenicity and carcinogenicity. The present study was carried out to evaluate the antioxidant activity of ethanolic extract of Tinospora cordifolia (EETC) in N-nitrosodiethylamine (DEN) induced liver cancer in male Wister albino rats. The antioxidant activity was assessed by the levels of lipid peroxidation (LPO), enzymic and nonenzymic antioxidants. A significant levels of LPO was increased as the enzymic and nonenzymic antioxidants values were decreased in liver cancer bearing animals. The administration of EETC to cancer bearing animals reverted the LPO levels, enzymic and nonenzymic antioxidants to near normal.
ISSN:0976-4879
0975-7406
0975-7406
0976-4879
DOI:10.4103/0975-7406.155791