Comparative metabolic study of the chloroform fraction of three Cystoseira species based on UPLC/ESI/MS analysis and biological activities

This study aims to investigate the phytoconstituents of the chloroform fraction of three spp. namely , , and using UPLC/ESI/MS technique. The results revealed the identification of 19, 20 and 11 metabolites in , , and respectively mainly terpenoids, flavonoids, phenolic acids and fatty acids. Also,...

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Published in:Journal of enzyme inhibition and medicinal chemistry 2024-12, Vol.39 (1), p.2292482-2292482
Main Authors: Aly, Shaza H, Elissawy, Ahmed M, El Hassab, Mahmoud A, Majrashi, Taghreed A, Hassan, Fatma E, Elkaeed, Eslam B, Eldehna, Wagdy M, Singab, Abdel Nasser B
Format: Article
Language:English
Subjects:
anti-inflammatory
antihyperglycemic
Antioxidants
brown algae
molecular docking
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Summary:This study aims to investigate the phytoconstituents of the chloroform fraction of three spp. namely , , and using UPLC/ESI/MS technique. The results revealed the identification of 19, 20 and 11 metabolites in , , and respectively mainly terpenoids, flavonoids, phenolic acids and fatty acids. Also, an antioxidant study using FRAP and DPPH assays was conducted where the chloroform fraction of displayed the highest antioxidant activity in both assays, which would be attributed to its highest total phenolics and total flavonoids. Besides, the investigation of COX-1, -glucosidase and -amylase inhibitory activities were performed. Regarding it showed the strongest inhibitory activity towards COX-1. Moreover, it showed potent inhibitory activity towards -glucosidase and -amylase enzymes. According to the molecular docking studies, the major compounds characterised showed efficient binding to the active sites of the target enzymes.
ISSN:1475-6366
1475-6374
DOI:10.1080/14756366.2023.2292482