Cord Blood Platelet Lysate: In Vitro Evaluation to Support the Use in Regenerative Medicine

Platelet-rich plasma (PRP) is an inexpensive and safe substitute of recombinant growth factors and . Due to its putative effect on tissue repair, the use of autologous PRP has become largely popular. Recently, a jellified PRP derivative obtained from umbilical cord blood (CB) has been utilized to tr...

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Bibliographic Details
Published in:Mediterranean journal of hematology and infectious diseases 2019-01, Vol.11 (1), p.e2019021-e2019021
Main Authors: Valentini, Caterina Giovanna, Nuzzolo, Eugenia Rosa, Bianchi, Maria, Orlando, Nicoletta, Iachininoto, Maria Grazia, Pinci, Priscilla, Teofili, Luciana
Format: Article
Language:English
Subjects:
cord blood
damage tissue healing
Original
Platelet lysate
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Summary:Platelet-rich plasma (PRP) is an inexpensive and safe substitute of recombinant growth factors and . Due to its putative effect on tissue repair, the use of autologous PRP has become largely popular. Recently, a jellified PRP derivative obtained from umbilical cord blood (CB) has been utilized to treat mucosal and cutaneous lesions. Nevertheless, whether PRP derived from CB and adult blood display different potency in promoting cell growth has been rarely investigated. In this study, we compared cytokine profile and mesenchymal cell growth supporting the ability of platelet lysate obtained from adult and cord blood. Our results strongly back the utilization of CB platelet lysate , as an efficacious, safe and inexpensive alternative to promote damaged tissue healing when the autologous PRP is contraindicated. Moreover, the policy of manufacturing CB platelet lysate can limit the current disposal of many collected CB units not suitable for transplant due to their low nucleated cell count.
ISSN:2035-3006
2035-3006
DOI:10.4084/MJHID.2019.021