The potential of plant extracts in cell therapy

Cell therapy is the frontier technology of biotechnology innovation and the most promising method for the treatment of refractory diseases such as tumours. However, cell therapy has disadvantages, such as toxicity and poor therapeutic effects. Plant extracts are natural, widely available, and contai...

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Published in:Stem cell research & therapy 2022-09, Vol.13 (1), p.1-472, Article 472
Main Authors: Li, Caifeng, Cui, Zhao, Deng, Shiwen, Chen, Peng, Li, Xianyu, Yang, Hongjun
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
Apoptosis
Autophagy
Biological products
Bone marrow
Cancer therapies
CAR-T
Cell cycle
Cell differentiation
Cell growth
Cell proliferation
Cell therapy
Chimeric antigen receptors
Flavonoids
Health aspects
Herbal medicine
Immunotherapy
Innovations
Lymphocytes T
Medical research
Medicine, Experimental
Mesenchyme
Plant extracts
Review
Stem cell
Stem cells
T cell receptors
T cells
TCR-T
Toxicity
Transplantation
Tumors
Type 2 diabetes
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Summary:Cell therapy is the frontier technology of biotechnology innovation and the most promising method for the treatment of refractory diseases such as tumours. However, cell therapy has disadvantages, such as toxicity and poor therapeutic effects. Plant extracts are natural, widely available, and contain active small molecule ingredients that are widely used in the treatment of various diseases. By studying the effect of plant extracts on cell therapy, active plant extracts that have positive significance in cell therapy can be discovered, and certain contributions to solving the current problems of attenuation and adjuvant therapy in cell therapy can be made. Therefore, this article reviews the currently reported effects of plant extracts in stem cell therapy and immune cell therapy, especially the effects of plant extracts on the proliferation and differentiation of mesenchymal stem cells and nerve stem cells and the potential role of plant extracts in chimeric antigen receptor T-cell immunotherapy (CAR-T) and T-cell receptor modified T-cell immunotherapy (TCR-T), in the hope of encouraging further research and clinical application of plant extracts in cell therapy.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-022-03152-z