The role of long non-coding RNAs in the pathogenesis of hereditary diseases

Thousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can drive tumorigenesis and they are now considered to be a promising therapeutic target in cancer...

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Bibliographic Details
Published in:BMC medical genomics 2019-03, Vol.12 (Suppl 2), p.42-42, Article 42
Main Authors: Sparber, Peter, Filatova, Alexandra, Khantemirova, Mira, Skoblov, Mikhail
Format: Article
Language:English
Subjects:
Angelman Syndrome - genetics
Angelman Syndrome - pathology
Atrophy
Beckwith-Wiedemann Syndrome - genetics
Beckwith-Wiedemann Syndrome - pathology
Biomarkers - metabolism
Cancer
Care and treatment
Deoxyribonucleic acid
Disease
DNA
DNA methylation
Gene expression
Gene regulation
Genes
Genetic Diseases, Inborn - genetics
Genetic Diseases, Inborn - pathology
Genetic disorders
Genetic regulation
Genetics
Genome-Wide Association Study
Genomes
Genomics
Hereditary disease
Hereditary diseases
Human genome
Humans
lncRNA
Long non-coding RNA
Medical genetics
Medical law
Messenger RNA
Mitochondrial DNA
Molecular biology
Molecular genetics
Non-coding RNA
Pathogenesis
Prader-Willi Syndrome - genetics
Prader-Willi Syndrome - pathology
Proteins
Pseudohypoparathyroidism - genetics
Pseudohypoparathyroidism - pathology
Review
RNA
RNA polymerase
RNA, Long Noncoding - metabolism
Silver-Russell Syndrome - genetics
Silver-Russell Syndrome - pathology
Therapeutic applications
Tumorigenesis
Tumors
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Summary:Thousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can drive tumorigenesis and they are now considered to be a promising therapeutic target in cancer. However, how lncRNAs contribute to the development of hereditary diseases in human is still mostly unknown. This review is focused on hereditary diseases in the pathogenesis of which long non-coding RNAs play an important role. Fundamental research in the field of molecular genetics of lncRNA is necessary for a more complete understanding of their significance. Future research will help translate this knowledge into clinical practice which will not only lead to an increase in the diagnostic rate but also in the future can help with the development of etiotropic treatments for hereditary diseases.
ISSN:1755-8794
1755-8794
DOI:10.1186/s12920-019-0487-6