Loading…

The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions

Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior. Aims: The aim of this study was to evaluateTROP-2 expressio...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of pathology & microbiology 2019-04, Vol.62 (2), p.206-210
Main Authors: Sadullahoğlu, Canan, Sayıner, Alper, Süren, Dinç, Yıldırım, Hülya, Nergiz, Döndü, Sezer, Cem, Oruç, Mehmet
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c480t-d4f24c962acb164edee2f770844c2ce3b0059a25bd515d8310ae705bb0c0a3213
cites cdi_FETCH-LOGICAL-c480t-d4f24c962acb164edee2f770844c2ce3b0059a25bd515d8310ae705bb0c0a3213
container_end_page 210
container_issue 2
container_start_page 206
container_title Indian journal of pathology & microbiology
container_volume 62
creator Sadullahoğlu, Canan
Sayıner, Alper
Süren, Dinç
Yıldırım, Hülya
Nergiz, Döndü
Sezer, Cem
Oruç, Mehmet
description Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior. Aims: The aim of this study was to evaluateTROP-2 expression in thyroid neoplasms. Subjects and Methods: This study contained 152 cases, including 48 follicular nodular disease (FND), 29 follicular adenoma (FA), 57 papillary thyroid carcinoma (PTC), 12 follicular thyroid carcinoma (FTC), 3 medullary thyroid carcinoma (MTC), 2 poorly differentiated thyroid carcinoma (PDTC) and 1 undifferentiated thyroid carcinoma (UDTC). TROP-2 expression was investigated via immunohistochemistry in sections prepared from paraffin blocks of the cases. Results: The cases comprised 32 (21%) males and 120 (79%) females with a mean age of 46.8 years (range, 15-85 years). TROP-2 expression was observed in 74.6% of the malignant lesions of the thyroid except for medullary carcinoma, poorly differentiated and undifferentiated thyroid carcinoma. Immunoreactivity was 3.4% in FA, 41.7% of cases with FTC and 81.8% in PTC follicular variant (PTC fv). The difference between FA/FTC and FA/PTC follicular variant were both significant (P < 0.005, P < 0.001, respectively). There was no difference between FTC/PTC fv (P = 0.089). Conclusion: TROP-2 can be considered a useful marker for distinguishing PTC fv cases from follicular nodular disease and follicular adenoma cases because of its high sensitivity in the identification of papillary carcinomas of the thyroid.
doi_str_mv 10.4103/IJPM.IJPM_202_18
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_4b091890f73f42b9b6dcdb3f04e27dc8</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A582072696</galeid><doaj_id>oai_doaj_org_article_4b091890f73f42b9b6dcdb3f04e27dc8</doaj_id><sourcerecordid>A582072696</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-d4f24c962acb164edee2f770844c2ce3b0059a25bd515d8310ae705bb0c0a3213</originalsourceid><addsrcrecordid>eNp1kklvFDEQhVsIRBa4c0ItceHSg7fejlGUkEFBcAhny0t5xpMee7C7NeTfU51JwiKQJVfJ9dWzy3pF8YaShaCEf1h--vp5MW-SESZp96w4Jn0rqppy8hxz3raV6Fl_VJzkvCGkEazmL4sjjhStBT0uxps1lNarVYh59KbMfhW880YFA2V05Zjibh31oPJYGhiGKk_JKaypMPoVhIqV8GOXIGcfQ-lDqSGgBJZtuVUDpgiW4_ouRW_LAWYsvypeODVkeP0QT4tvlxc351fV9ZePy_Oz68qIjoyVFY4J0zdMGU0bARaAubYlnRCGGeCakLpXrNa2prXtOCUKWlJrTQxRnFF-WiwPujaqjdwlv1XpTkbl5f1BTCupEk49gBSa9LTriWu5E0z3urHGau6IANZa06HW-4PWLsXvE-RRbn2ef0QFiFOWjJG2F3ipQPTdX-gmTingpEjV-O2Ck-YXtVJ4vw8ujkmZWVSe1R2qsaafqcU_KFwWtt7EAM7j-R8N5NBgUsw5gXuamxI5m0be--U302DL24f3TnoL9qnh0SUIXB6AfRxGSPl2mPaQJLK3Ie7_K4yhkegv-egv_hNDkdUV</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2255414306</pqid></control><display><type>article</type><title>The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions</title><source>Publicly Available Content (ProQuest)</source><creator>Sadullahoğlu, Canan ; Sayıner, Alper ; Süren, Dinç ; Yıldırım, Hülya ; Nergiz, Döndü ; Sezer, Cem ; Oruç, Mehmet</creator><creatorcontrib>Sadullahoğlu, Canan ; Sayıner, Alper ; Süren, Dinç ; Yıldırım, Hülya ; Nergiz, Döndü ; Sezer, Cem ; Oruç, Mehmet</creatorcontrib><description>Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior. Aims: The aim of this study was to evaluateTROP-2 expression in thyroid neoplasms. Subjects and Methods: This study contained 152 cases, including 48 follicular nodular disease (FND), 29 follicular adenoma (FA), 57 papillary thyroid carcinoma (PTC), 12 follicular thyroid carcinoma (FTC), 3 medullary thyroid carcinoma (MTC), 2 poorly differentiated thyroid carcinoma (PDTC) and 1 undifferentiated thyroid carcinoma (UDTC). TROP-2 expression was investigated via immunohistochemistry in sections prepared from paraffin blocks of the cases. Results: The cases comprised 32 (21%) males and 120 (79%) females with a mean age of 46.8 years (range, 15-85 years). TROP-2 expression was observed in 74.6% of the malignant lesions of the thyroid except for medullary carcinoma, poorly differentiated and undifferentiated thyroid carcinoma. Immunoreactivity was 3.4% in FA, 41.7% of cases with FTC and 81.8% in PTC follicular variant (PTC fv). The difference between FA/FTC and FA/PTC follicular variant were both significant (P &lt; 0.005, P &lt; 0.001, respectively). There was no difference between FTC/PTC fv (P = 0.089). Conclusion: TROP-2 can be considered a useful marker for distinguishing PTC fv cases from follicular nodular disease and follicular adenoma cases because of its high sensitivity in the identification of papillary carcinomas of the thyroid.</description><identifier>ISSN: 0377-4929</identifier><identifier>EISSN: 0974-5130</identifier><identifier>DOI: 10.4103/IJPM.IJPM_202_18</identifier><identifier>PMID: 30971541</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Adenocarcinoma, Follicular - diagnosis ; Adenoma ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alcohol ; Antigens ; Antigens, Neoplasm - genetics ; Carcinoma ; Carcinoma, Neuroendocrine - diagnosis ; Cases (containers) ; Cell Adhesion Molecules - genetics ; Cell surface ; Diagnosis ; Diagnostic systems ; Endocrine system ; Female ; Females ; Follicular neoplasm ; Gene expression ; Genetic aspects ; Glycoproteins ; Hospitals ; Humans ; Immunohistochemistry ; Lesions ; Male ; Males ; Malignancy ; Middle Aged ; Neoplasms ; Overexpression ; Papillary thyroid carcinoma ; Paraffin ; Paraffins ; Statistical analysis ; Studies ; Thyroid ; Thyroid cancer ; Thyroid Cancer, Papillary - diagnosis ; thyroid carcinoma ; Thyroid diseases ; Thyroid Gland - pathology ; Thyroid Neoplasms - diagnosis ; TROP-2 ; Tumors ; Young Adult</subject><ispartof>Indian journal of pathology &amp; microbiology, 2019-04, Vol.62 (2), p.206-210</ispartof><rights>COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd.</rights><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-d4f24c962acb164edee2f770844c2ce3b0059a25bd515d8310ae705bb0c0a3213</citedby><cites>FETCH-LOGICAL-c480t-d4f24c962acb164edee2f770844c2ce3b0059a25bd515d8310ae705bb0c0a3213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2255414306?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30971541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sadullahoğlu, Canan</creatorcontrib><creatorcontrib>Sayıner, Alper</creatorcontrib><creatorcontrib>Süren, Dinç</creatorcontrib><creatorcontrib>Yıldırım, Hülya</creatorcontrib><creatorcontrib>Nergiz, Döndü</creatorcontrib><creatorcontrib>Sezer, Cem</creatorcontrib><creatorcontrib>Oruç, Mehmet</creatorcontrib><title>The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions</title><title>Indian journal of pathology &amp; microbiology</title><addtitle>Indian J Pathol Microbiol</addtitle><description>Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior. Aims: The aim of this study was to evaluateTROP-2 expression in thyroid neoplasms. Subjects and Methods: This study contained 152 cases, including 48 follicular nodular disease (FND), 29 follicular adenoma (FA), 57 papillary thyroid carcinoma (PTC), 12 follicular thyroid carcinoma (FTC), 3 medullary thyroid carcinoma (MTC), 2 poorly differentiated thyroid carcinoma (PDTC) and 1 undifferentiated thyroid carcinoma (UDTC). TROP-2 expression was investigated via immunohistochemistry in sections prepared from paraffin blocks of the cases. Results: The cases comprised 32 (21%) males and 120 (79%) females with a mean age of 46.8 years (range, 15-85 years). TROP-2 expression was observed in 74.6% of the malignant lesions of the thyroid except for medullary carcinoma, poorly differentiated and undifferentiated thyroid carcinoma. Immunoreactivity was 3.4% in FA, 41.7% of cases with FTC and 81.8% in PTC follicular variant (PTC fv). The difference between FA/FTC and FA/PTC follicular variant were both significant (P &lt; 0.005, P &lt; 0.001, respectively). There was no difference between FTC/PTC fv (P = 0.089). Conclusion: TROP-2 can be considered a useful marker for distinguishing PTC fv cases from follicular nodular disease and follicular adenoma cases because of its high sensitivity in the identification of papillary carcinomas of the thyroid.</description><subject>Adenocarcinoma, Follicular - diagnosis</subject><subject>Adenoma</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcohol</subject><subject>Antigens</subject><subject>Antigens, Neoplasm - genetics</subject><subject>Carcinoma</subject><subject>Carcinoma, Neuroendocrine - diagnosis</subject><subject>Cases (containers)</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell surface</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Endocrine system</subject><subject>Female</subject><subject>Females</subject><subject>Follicular neoplasm</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Glycoproteins</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lesions</subject><subject>Male</subject><subject>Males</subject><subject>Malignancy</subject><subject>Middle Aged</subject><subject>Neoplasms</subject><subject>Overexpression</subject><subject>Papillary thyroid carcinoma</subject><subject>Paraffin</subject><subject>Paraffins</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid Cancer, Papillary - diagnosis</subject><subject>thyroid carcinoma</subject><subject>Thyroid diseases</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>TROP-2</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0377-4929</issn><issn>0974-5130</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kklvFDEQhVsIRBa4c0ItceHSg7fejlGUkEFBcAhny0t5xpMee7C7NeTfU51JwiKQJVfJ9dWzy3pF8YaShaCEf1h--vp5MW-SESZp96w4Jn0rqppy8hxz3raV6Fl_VJzkvCGkEazmL4sjjhStBT0uxps1lNarVYh59KbMfhW880YFA2V05Zjibh31oPJYGhiGKk_JKaypMPoVhIqV8GOXIGcfQ-lDqSGgBJZtuVUDpgiW4_ouRW_LAWYsvypeODVkeP0QT4tvlxc351fV9ZePy_Oz68qIjoyVFY4J0zdMGU0bARaAubYlnRCGGeCakLpXrNa2prXtOCUKWlJrTQxRnFF-WiwPujaqjdwlv1XpTkbl5f1BTCupEk49gBSa9LTriWu5E0z3urHGau6IANZa06HW-4PWLsXvE-RRbn2ef0QFiFOWjJG2F3ipQPTdX-gmTingpEjV-O2Ck-YXtVJ4vw8ujkmZWVSe1R2qsaafqcU_KFwWtt7EAM7j-R8N5NBgUsw5gXuamxI5m0be--U302DL24f3TnoL9qnh0SUIXB6AfRxGSPl2mPaQJLK3Ie7_K4yhkegv-egv_hNDkdUV</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Sadullahoğlu, Canan</creator><creator>Sayıner, Alper</creator><creator>Süren, Dinç</creator><creator>Yıldırım, Hülya</creator><creator>Nergiz, Döndü</creator><creator>Sezer, Cem</creator><creator>Oruç, Mehmet</creator><general>Wolters Kluwer India Pvt. Ltd</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications &amp; Media Pvt. Ltd</general><general>Wolters Kluwer Medknow Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20190401</creationdate><title>The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions</title><author>Sadullahoğlu, Canan ; Sayıner, Alper ; Süren, Dinç ; Yıldırım, Hülya ; Nergiz, Döndü ; Sezer, Cem ; Oruç, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-d4f24c962acb164edee2f770844c2ce3b0059a25bd515d8310ae705bb0c0a3213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenocarcinoma, Follicular - diagnosis</topic><topic>Adenoma</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcohol</topic><topic>Antigens</topic><topic>Antigens, Neoplasm - genetics</topic><topic>Carcinoma</topic><topic>Carcinoma, Neuroendocrine - diagnosis</topic><topic>Cases (containers)</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell surface</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Endocrine system</topic><topic>Female</topic><topic>Females</topic><topic>Follicular neoplasm</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Glycoproteins</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lesions</topic><topic>Male</topic><topic>Males</topic><topic>Malignancy</topic><topic>Middle Aged</topic><topic>Neoplasms</topic><topic>Overexpression</topic><topic>Papillary thyroid carcinoma</topic><topic>Paraffin</topic><topic>Paraffins</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid Cancer, Papillary - diagnosis</topic><topic>thyroid carcinoma</topic><topic>Thyroid diseases</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>TROP-2</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sadullahoğlu, Canan</creatorcontrib><creatorcontrib>Sayıner, Alper</creatorcontrib><creatorcontrib>Süren, Dinç</creatorcontrib><creatorcontrib>Yıldırım, Hülya</creatorcontrib><creatorcontrib>Nergiz, Döndü</creatorcontrib><creatorcontrib>Sezer, Cem</creatorcontrib><creatorcontrib>Oruç, Mehmet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Directory of Open Access Journals</collection><jtitle>Indian journal of pathology &amp; microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sadullahoğlu, Canan</au><au>Sayıner, Alper</au><au>Süren, Dinç</au><au>Yıldırım, Hülya</au><au>Nergiz, Döndü</au><au>Sezer, Cem</au><au>Oruç, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions</atitle><jtitle>Indian journal of pathology &amp; microbiology</jtitle><addtitle>Indian J Pathol Microbiol</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>62</volume><issue>2</issue><spage>206</spage><epage>210</epage><pages>206-210</pages><issn>0377-4929</issn><eissn>0974-5130</eissn><abstract>Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior. Aims: The aim of this study was to evaluateTROP-2 expression in thyroid neoplasms. Subjects and Methods: This study contained 152 cases, including 48 follicular nodular disease (FND), 29 follicular adenoma (FA), 57 papillary thyroid carcinoma (PTC), 12 follicular thyroid carcinoma (FTC), 3 medullary thyroid carcinoma (MTC), 2 poorly differentiated thyroid carcinoma (PDTC) and 1 undifferentiated thyroid carcinoma (UDTC). TROP-2 expression was investigated via immunohistochemistry in sections prepared from paraffin blocks of the cases. Results: The cases comprised 32 (21%) males and 120 (79%) females with a mean age of 46.8 years (range, 15-85 years). TROP-2 expression was observed in 74.6% of the malignant lesions of the thyroid except for medullary carcinoma, poorly differentiated and undifferentiated thyroid carcinoma. Immunoreactivity was 3.4% in FA, 41.7% of cases with FTC and 81.8% in PTC follicular variant (PTC fv). The difference between FA/FTC and FA/PTC follicular variant were both significant (P &lt; 0.005, P &lt; 0.001, respectively). There was no difference between FTC/PTC fv (P = 0.089). Conclusion: TROP-2 can be considered a useful marker for distinguishing PTC fv cases from follicular nodular disease and follicular adenoma cases because of its high sensitivity in the identification of papillary carcinomas of the thyroid.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>30971541</pmid><doi>10.4103/IJPM.IJPM_202_18</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0377-4929
ispartof Indian journal of pathology & microbiology, 2019-04, Vol.62 (2), p.206-210
issn 0377-4929
0974-5130
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_4b091890f73f42b9b6dcdb3f04e27dc8
source Publicly Available Content (ProQuest)
subjects Adenocarcinoma, Follicular - diagnosis
Adenoma
Adolescent
Adult
Aged
Aged, 80 and over
Alcohol
Antigens
Antigens, Neoplasm - genetics
Carcinoma
Carcinoma, Neuroendocrine - diagnosis
Cases (containers)
Cell Adhesion Molecules - genetics
Cell surface
Diagnosis
Diagnostic systems
Endocrine system
Female
Females
Follicular neoplasm
Gene expression
Genetic aspects
Glycoproteins
Hospitals
Humans
Immunohistochemistry
Lesions
Male
Males
Malignancy
Middle Aged
Neoplasms
Overexpression
Papillary thyroid carcinoma
Paraffin
Paraffins
Statistical analysis
Studies
Thyroid
Thyroid cancer
Thyroid Cancer, Papillary - diagnosis
thyroid carcinoma
Thyroid diseases
Thyroid Gland - pathology
Thyroid Neoplasms - diagnosis
TROP-2
Tumors
Young Adult
title The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A35%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20diagnostic%20significance%20of%20trophoblast%20cell-surface%20antigen-2%20expression%20in%20benign%20and%20malignant%20thyroid%20lesions&rft.jtitle=Indian%20journal%20of%20pathology%20&%20microbiology&rft.au=Sadullaho%C4%9Flu,%20Canan&rft.date=2019-04-01&rft.volume=62&rft.issue=2&rft.spage=206&rft.epage=210&rft.pages=206-210&rft.issn=0377-4929&rft.eissn=0974-5130&rft_id=info:doi/10.4103/IJPM.IJPM_202_18&rft_dat=%3Cgale_doaj_%3EA582072696%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c480t-d4f24c962acb164edee2f770844c2ce3b0059a25bd515d8310ae705bb0c0a3213%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2255414306&rft_id=info:pmid/30971541&rft_galeid=A582072696&rfr_iscdi=true