Improvement of Cardiac Vegetations in Antiphospholipid Syndrome with Enoxaparin and Corticosteroids after Rivaroxaban Failure

Cardiac disease is a well-known complication of antiphospholipid syndrome (APS), with many patients presenting with valvular thickening or vegetations, referred to as Libman–Sacks endocarditis (LSE). Because cases of APS with cardiac involvement are relatively rare, paucity of large clinical trials...

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Bibliographic Details
Published in:Case reports in hematology 2018-01, Vol.2018 (2018), p.1-4
Main Authors: Granowicz, Eric, Chung, Kiyon
Format: Article
Language:English
Subjects:
Anticoagulants
Antiphospholipid syndrome
Autoimmune diseases
Cardiovascular disease
Case Report
Case reports
Corticosteroids
Disease prevention
Endocarditis
Evidence-based medicine
Family medical history
Heart failure
Immunoglobulins
Lupus
Medical research
Medicine, Experimental
Patients
Rivaroxaban
Surgery
Thrombosis
Ultrasonic imaging
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Summary:Cardiac disease is a well-known complication of antiphospholipid syndrome (APS), with many patients presenting with valvular thickening or vegetations, referred to as Libman–Sacks endocarditis (LSE). Because cases of APS with cardiac involvement are relatively rare, paucity of large clinical trials studying this complication has made management challenging. In the absence of acute heart failure and embolic events, a medical approach is usually selected, consisting of anticoagulation and possibly corticosteroids when another underlying autoimmune disease is present. However, the role of various anticoagulant classes and the duration of steroid therapy continue to be debated. Here, we present a 45-year-old woman who developed two vegetations in the setting of secondary APS while taking rivaroxaban before experiencing marked improvement with the use of enoxaparin and steroids.
ISSN:2090-6560
2090-6579
DOI:10.1155/2018/8097539