Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute inflammatory lung condition which currently has no specific treatments targeting its pathophysiology. However, mesenchymal stem cells have been shown to have very promising therapeutic potential, and recently, it has...

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Bibliographic Details
Published in:Stem cells translational medicine 2020-01, Vol.9 (1), p.28-38
Main Authors: Abraham, Aswin, Krasnodembskaya, Anna
Format: Article
Language:English
Subjects:
Antigens
Biomarkers
cellular therapy
clinical translation
Clinical trials
Concise Review
Cytokines
Edema
Extracellular vesicles
Extracellular Vesicles - transplantation
Growth factors
Humans
Inflammation
Lungs
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal stem cells
mesenchymal stem cells (MSCs)
Mesenchymal Stem Cells - metabolism
miRNA
Mitochondria
Mortality
mRNA
Organelles
Patients
Respiratory distress syndrome
Respiratory Distress Syndrome - therapy
respiratory tract
Sepsis
Stem cells
Tumors
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Summary:Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute inflammatory lung condition which currently has no specific treatments targeting its pathophysiology. However, mesenchymal stem cells have been shown to have very promising therapeutic potential, and recently, it has been established that their effect is largely due to the transfer of extracellular vesicles (EVs). EVs have been shown to transfer a variety of substances such as mRNA, miRNA, and even organelles such as mitochondria in order to ameliorate ARDS in preclinical models. In addition, the fact that they have been proven to have the same effect as their parent cells combined with their numerous advantages over whole cell administration means that they are a promising candidate for clinical application that merits further research.
ISSN:2157-6564
2157-6580
DOI:10.1002/sctm.19-0205