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Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle

We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colon...

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Published in:Stem Cells International 2013-01, Vol.2013 (2013), p.55-68
Main Authors: Song, Shuojing, Lin, Xiaoyang, Song, Shijie, Sanchez-Ramos, Juan, Sava, Vasyl, Li, Kunyu, Cao, Chuanhai
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cited_by cdi_FETCH-LOGICAL-a669t-c128e792d41aa6da7de6acae25c9d99c0cc0243b8c9f430a10c2b8c88adf9fb93
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container_title Stem Cells International
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creator Song, Shuojing
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description We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis. This study describes immediate and early humoral and cellular mechanisms of the brain’s response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders.
doi_str_mv 10.1155/2013/205878
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subjects Brain
Brain research
Cellular control mechanisms
Genetic aspects
Injuries
Neurogenesis
title Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle
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