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Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle
We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colon...
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Published in: | Stem Cells International 2013-01, Vol.2013 (2013), p.55-68 |
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creator | Song, Shuojing Lin, Xiaoyang Song, Shijie Sanchez-Ramos, Juan Sava, Vasyl Li, Kunyu Cao, Chuanhai |
description | We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis. This study describes immediate and early humoral and cellular mechanisms of the brain’s response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders. |
doi_str_mv | 10.1155/2013/205878 |
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This study describes immediate and early humoral and cellular mechanisms of the brain’s response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders.</description><identifier>ISSN: 1687-966X</identifier><identifier>ISSN: 1687-9678</identifier><identifier>EISSN: 1687-9678</identifier><identifier>DOI: 10.1155/2013/205878</identifier><identifier>PMID: 23554817</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Brain ; Brain research ; Cellular control mechanisms ; Genetic aspects ; Injuries ; Neurogenesis</subject><ispartof>Stem Cells International, 2013-01, Vol.2013 (2013), p.55-68</ispartof><rights>Copyright © 2013 Shijie Song et al.</rights><rights>COPYRIGHT 2013 John Wiley & Sons, Inc.</rights><rights>Copyright © 2013 Shijie Song et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a669t-c128e792d41aa6da7de6acae25c9d99c0cc0243b8c9f430a10c2b8c88adf9fb93</citedby><cites>FETCH-LOGICAL-a669t-c128e792d41aa6da7de6acae25c9d99c0cc0243b8c9f430a10c2b8c88adf9fb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608357/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608357/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23554817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Breunig, Joshua J.</contributor><creatorcontrib>Song, Shuojing</creatorcontrib><creatorcontrib>Lin, Xiaoyang</creatorcontrib><creatorcontrib>Song, Shijie</creatorcontrib><creatorcontrib>Sanchez-Ramos, Juan</creatorcontrib><creatorcontrib>Sava, Vasyl</creatorcontrib><creatorcontrib>Li, Kunyu</creatorcontrib><creatorcontrib>Cao, Chuanhai</creatorcontrib><title>Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle</title><title>Stem Cells International</title><addtitle>Stem Cells Int</addtitle><description>We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. 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source | Open Access: Wiley-Blackwell Open Access Journals; PubMed Central |
subjects | Brain Brain research Cellular control mechanisms Genetic aspects Injuries Neurogenesis |
title | Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle |
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