Constituintes químicos das folhas e avaliação da atividade anti-inflamatória de extratos das raízes e folhas de Guettarda pohliana Müll. Arg. (Rubiaceae)

This phytochemical investigation of Guettarda pohliana leaves led to the isolation of the triterpenes pomolic acid, rotundic acid, 3β,6α,19α,23-tetrahydroxyurs-12-en-28-oic acid, clethric acid, ursolic acid and oleanolic acid, the monoterpenoids loliolide and secoxyloganin, besides daucosterol and s...

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Bibliographic Details
Published in:Química Nova 2012-01, Vol.35 (3), p.527-529
Main Authors: Gláucio Testa, Paulo Roberto Neves de Oliveira, Cleuza Conceição da Silva, Ivânia Teresinha Albrecht Schuquel, Silvana Maria de Oliveira Santin, Lucília Kato, Cecília Maria Alves de Oliveira, Laura Lícia Milani de Arruda, Ciomar Aparecida Bersani-Amado
Format: Article
Language:English
Subjects:
anti-inflammatory activity
Guettarda pohliana
triterpenoid
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Summary:This phytochemical investigation of Guettarda pohliana leaves led to the isolation of the triterpenes pomolic acid, rotundic acid, 3β,6α,19α,23-tetrahydroxyurs-12-en-28-oic acid, clethric acid, ursolic acid and oleanolic acid, the monoterpenoids loliolide and secoxyloganin, besides daucosterol and steroids. The structures of the isolated compounds were assigned on the basis of NMR data, including two-dimensional NMR methods. The anti-inflammatory activity of the crude methanolic extracts from leaves and roots, as well as of their fractions, was evaluated.
ISSN:1678-7064
DOI:10.1590/S0100-40422012000300016