Gut Microbiota and Enteral Nutrition Tolerance in Non-Abdominal Infection Septic ICU Patients: An Observational Study

The effect of gut microbiota on enteral nutrition tolerance in critically ill patients is unclear. Non-abdominal sepsis patients in an ICU, sorted by whether they reached 20 Kcal/kg/day on the 3rd day of EN, were divided into tolerance and intolerance groups. Their feces on day 1 and day 3 of EN ini...

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Bibliographic Details
Published in:Nutrients 2022-12, Vol.14 (24), p.5342
Main Authors: Xu, Wen, Zhong, Ming, Pan, Tingting, Qu, Hongping, Chen, Erzhen
Format: Article
Language:English
Subjects:
Bacteroidetes
Critical Illness
Critically ill
Diet therapy
Enteral feeding
Enteral Nutrition
enteral nutrition tolerance
Fatty acids
Firmicutes
Gastrointestinal Microbiome - genetics
Gastrointestinal system
Health aspects
Humans
Infections
Intensive Care Units
Intestinal microflora
Intolerance
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Motility
Nutrition
Observational studies
Patients
Physiological aspects
rRNA 16S
Sepsis
Software
Tube feeding
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Summary:The effect of gut microbiota on enteral nutrition tolerance in critically ill patients is unclear. Non-abdominal sepsis patients in an ICU, sorted by whether they reached 20 Kcal/kg/day on the 3rd day of EN, were divided into tolerance and intolerance groups. Their feces on day 1 and day 3 of EN initiation were collected for 16s rDNA and short-chain fatty acid (SCFA) testing. There were 14 patients included in the tolerance group and 10 in the intolerance group. On EN day 1, the OTUs and microbiota diversity were higher in the tolerance group than in the intolerance group. The ratio of Firmicutes to Bacteroidetes was higher in the intolerance group on EN day 1. The genus Parabacteroides were the most significantly elevated in the tolerance group. On EN day 3, the genus Escherichia-Shigella was the most significantly elevated in the tolerance group. On EN day 3, the levels of SCFA decreased more significantly in the intolerance group. Enteral nutrition tolerance is associated with microbiota features and short-chain fatty acid levels. A higher ratio of Firmicutes to Bacteroidetes and microbiota diversity on EN day 1 may help in the early prediction of EN tolerance.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14245342